Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

185
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

153
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Evolvulus alsinoides methanolic extract triggers apoptosis in HepG2 cells

Pages

  504-512

Abstract

 Objective: The objective of the present study was to evaluate the cytotoxic potentials of Evolvulus alsinoides in human hepatoma HepG2 cells. Materials and Methods: HepG2 cells were treated with methanolic extract of E. alsinoides at 20, 40 and 80 μ g/ml for 24 hr and cytotoxic effect was analyzed by MTT assay. The Apoptosis rate was investigated by Hoechst 33342 and annexin V/propidium iodide staining. Mitochondrial membrane potential was evaluated by rhodamine staining. Also, the expression of catenin – β 1 protein was analyzed by western blotting. Results: E. alsinoides methanolic extract treatment caused significant Cytotoxicity in HepG2 cells in a concentration-dependent manner. Dual staining assay confirmed the presence of early and late apoptotic cells only in extract-treated groups. Plant extract treatment also caused nuclear fragmentation and chromatin condensation in HepG2 cells. Mitochondrial membrane potential also reduced upon E. alsinoides treatments. This treatment also modulated the catenin – β 1 protein expression. Conclusion: In this study, we demonstrated the proapoptotic potential E. alsinoides in HepG2 cells; thus, this plant may be beneficial in the treatment of liver cancer.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Ponselvi Induja, Murugan, Ezhilarasan, Devaraj, & Ashok Vardhan, Nandigam. (2018). Evolvulus alsinoides methanolic extract triggers apoptosis in HepG2 cells. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 8(6), 504-512. SID. https://sid.ir/paper/326464/en

    Vancouver: Copy

    Ponselvi Induja Murugan, Ezhilarasan Devaraj, Ashok Vardhan Nandigam. Evolvulus alsinoides methanolic extract triggers apoptosis in HepG2 cells. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2018;8(6):504-512. Available from: https://sid.ir/paper/326464/en

    IEEE: Copy

    Murugan Ponselvi Induja, Devaraj Ezhilarasan, and Nandigam Ashok Vardhan, “Evolvulus alsinoides methanolic extract triggers apoptosis in HepG2 cells,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 8, no. 6, pp. 504–512, 2018, [Online]. Available: https://sid.ir/paper/326464/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top