THE EFFECTS OF TOPIRAMATE ON MORPHINE SENSITIZATION IN MICE

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HOUSHMANDI Z.; SAHRAEI HEDAYAT; GHOSHOUNI H.; FATEMI M.; SHAMS J.

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Journal: KOWSAR MEDICAL JOURNAL Year:2007 | Volume:11 | Issue:4 Page(s): 315-324

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Title

THE EFFECTS OF TOPIRAMATE ON MORPHINE SENSITIZATION IN MICE

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Keywords

CONDITIONED PLACE PREFERENCEQ4

MORPHINEQ3

TOPIRAMATEQ3

DRUG SENSITIZATIONQ3

MICEQ3

Abstract

Objective: In the present study attempts were made to further identify the effects of TOPIRAMATE on the acquisition and expression of MORPHINE-induced CONDITIONED PLACE PREFERENCE in MORPHINE-sensitized MICE.Materials and Methods: Male Swiss-Webster MICE (20-30 g) were used in this study and un-biased place conditioning paradigm was applied for this purpose. In a pilot study, the effects of MORPHINE on place conditioning paradigm were assessed in MORPHINE-nave animals for evaluation of ineffective doses of the drug.Results: Administration of one dose daily MORPHINE (5 mg/kg) for 3 days followed by five days rest, in order to develop sensitization, enhanced the conditioning induced by ineffective MORPHINE (0.25, 0.5 and 1 mg/kg). Injections of TOPIRAMATE (20, 80 and 120 mg/kg, i.p.) reduced both the acquisition and expression of MORPHINE CPP in MORPHINEsensitized animals. TOPIRAMATE (20, 80 and 120 mg/kg, i.p.) by itself did not induce place preference or place aversion in the MICE.Conclusion: It can be concluded that to piramate administration leads to inhibition of MORPHINE sensitization, which may be due to glutamate and/or GABAergic mechanisms. In addition, it seems that TOPIRAMATE may be useful for treatment of psychological dependence to opioids.

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APA: Copy

HOUSHMANDI, Z., SAHRAEI, HEDAYAT, GHOSHOUNI, H., FATEMI, M., & SHAMS, J.. (2007). THE EFFECTS OF TOPIRAMATE ON MORPHINE SENSITIZATION IN MICE. KOWSAR MEDICAL JOURNAL, 11(4), 315-324. SID. https://sid.ir/paper/32727/en

Vancouver: Copy

HOUSHMANDI Z., SAHRAEI HEDAYAT, GHOSHOUNI H., FATEMI M., SHAMS J.. THE EFFECTS OF TOPIRAMATE ON MORPHINE SENSITIZATION IN MICE. KOWSAR MEDICAL JOURNAL[Internet]. 2007;11(4):315-324. Available from: https://sid.ir/paper/32727/en

IEEE: Copy

Z. HOUSHMANDI, HEDAYAT SAHRAEI, H. GHOSHOUNI, M. FATEMI, and J. SHAMS, “THE EFFECTS OF TOPIRAMATE ON MORPHINE SENSITIZATION IN MICE,” KOWSAR MEDICAL JOURNAL, vol. 11, no. 4, pp. 315–324, 2007, [Online]. Available: https://sid.ir/paper/32727/en

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