EFFECT OF UN-CONTROLLED PSYCHOLOGICAL AND PHYSICAL STRESS IN SMALL PREGNANT FEMALE NMRI MICE ON BEHAVIORAL SENSITIZATION INDUCED BY MORPHINE IN SECOND GENERATION

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YARI BEYGI H.A.; SAHRAEI HEDAYAT; GOLMANESH L.

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Journal: KOWSAR MEDICAL JOURNAL Year:2009 | Volume:14 | Issue:3 Page(s): 127-135

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Title

EFFECT OF UN-CONTROLLED PSYCHOLOGICAL AND PHYSICAL STRESS IN SMALL PREGNANT FEMALE NMRI MICE ON BEHAVIORAL SENSITIZATION INDUCED BY MORPHINE IN SECOND GENERATION

Author(s)

YARI BEYGI H.A. | SAHRAEI HEDAYAT | GOLMANESH L. | Issue Writer Certificate

Keywords

PSYCHOLOGICAL STRESSQ2

PHYSICAL STRESSQ3

MORPHINEQ3

SECOND GENERATIONQ3

Abstract

Aims: Researches about the effect of pregnant mothers stress on their children addiction to narcotics showed their increasing tendency to its abuse. In this research, the effect of pregnant females’ stress on changes of SECOND GENERATION tendency to MORPHINE was studied in small NMRI mice.Materials & Methods: 20 pregnant female NMRI mice were placed in two stress and control group. Stress group itself divided to two physical and psychological subgroups. To the 20th day of pregnancy, all mice were put in “stress box” for an hour a day. In first, 7th and 15th days the level of corticostrone hormone in their blood were tested. After reaching to 20-25 grams, F2 generation offsrings entered to study and the effects of 3 different doses of MORPHINE on behavioral sensitization were studied. The functions of dopamine activity, glutamate activity and NO activity were investigated.Results: Stress, increased the time of anorexia in stress group comparing to control group significantly. This results were consonant with the corticostrone hormone concentration changes. SECOND GENERATION mice that were born from stressed mothers responsed stronger to different MORPHINE injections comparing to control group (especially to 5 and 50 mg/kg). This was stronger in PSYCHOLOGICAL STRESS group. Dopamine activity, NO activity and Glutamate activity decreased in SECOND GENERATION offsprings. Conclusion: Stress, not only increases the tendency to MORPHINE in parents but also increases it in SECOND GENERATION offsprings.

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APA: Copy

YARI BEYGI, H.A., SAHRAEI, HEDAYAT, & GOLMANESH, L.. (2009). EFFECT OF UN-CONTROLLED PSYCHOLOGICAL AND PHYSICAL STRESS IN SMALL PREGNANT FEMALE NMRI MICE ON BEHAVIORAL SENSITIZATION INDUCED BY MORPHINE IN SECOND GENERATION. KOWSAR MEDICAL JOURNAL, 14(3), 127-135. SID. https://sid.ir/paper/32751/en

Vancouver: Copy

YARI BEYGI H.A., SAHRAEI HEDAYAT, GOLMANESH L.. EFFECT OF UN-CONTROLLED PSYCHOLOGICAL AND PHYSICAL STRESS IN SMALL PREGNANT FEMALE NMRI MICE ON BEHAVIORAL SENSITIZATION INDUCED BY MORPHINE IN SECOND GENERATION. KOWSAR MEDICAL JOURNAL[Internet]. 2009;14(3):127-135. Available from: https://sid.ir/paper/32751/en

IEEE: Copy

H.A. YARI BEYGI, HEDAYAT SAHRAEI, and L. GOLMANESH, “EFFECT OF UN-CONTROLLED PSYCHOLOGICAL AND PHYSICAL STRESS IN SMALL PREGNANT FEMALE NMRI MICE ON BEHAVIORAL SENSITIZATION INDUCED BY MORPHINE IN SECOND GENERATION,” KOWSAR MEDICAL JOURNAL, vol. 14, no. 3, pp. 127–135, 2009, [Online]. Available: https://sid.ir/paper/32751/en

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