ANTIDEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF AMARANTHUS SPINOSUS

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ASHOK KUMAR B.S.; LAKSHMAN K.; VELMURUGAN C.; SRIDHAR S.M.; GOPISETTY SARAN

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Journal Paper

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Journal: Basic and Clinical Neuroscience Year:2014 | Volume:5 | Issue:1 Page(s): 11-17

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Title

ANTIDEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF AMARANTHUS SPINOSUS

Author(s)

Keywords

ANTIDEPRESSANT ACTIVITY

AMARANTHUS SPINOSUS

ESCITALOPRAM

IMIPRAMINE

Abstract

Introduction: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. AMARANTHUS SPINOSUS was investigation for ANTIDEPRESSANT ACTIVITY.Methods: ANTIDEPRESSANT ACTIVITY of methanolic extract of AMARANTHUS SPINOSUS (MEAS) was investigated by using Forced swimming test (FST) and Tail suspension test (TST) models. ESCITALOPRAM and IMIPRAMINE were used as reference standards.Results: It has been observed from our study that both the MEAS at higher concentration showed significant (p<0.01) reduction in immobility in tail suspension and forced swim model of depression comparable to ESCITALOPRAM and IMIPRAMINE.Discussion: However further study is needed to understand mechanism of action and to identify active component responsible for antidepressant like activity.

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APA: Copy

ASHOK KUMAR, B.S., LAKSHMAN, K., VELMURUGAN, C., SRIDHAR, S.M., & GOPISETTY, SARAN. (2014). ANTIDEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF AMARANTHUS SPINOSUS. BASIC AND CLINICAL NEUROSCIENCE, 5(1), 11-17. SID. https://sid.ir/paper/327665/en

Vancouver: Copy

ASHOK KUMAR B.S., LAKSHMAN K., VELMURUGAN C., SRIDHAR S.M., GOPISETTY SARAN. ANTIDEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF AMARANTHUS SPINOSUS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2014;5(1):11-17. Available from: https://sid.ir/paper/327665/en

IEEE: Copy

B.S. ASHOK KUMAR, K. LAKSHMAN, C. VELMURUGAN, S.M. SRIDHAR, and SARAN GOPISETTY, “ANTIDEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF AMARANTHUS SPINOSUS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 5, no. 1, pp. 11–17, 2014, [Online]. Available: https://sid.ir/paper/327665/en

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