EFFECT OF LEVODOPA-B ON VISUAL ACUITY OF AMBLYOPIC EYES IN CHILDREN

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FARVARDIN M.; MAHDIZADEH M.

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Journal: KOWSAR MEDICAL JOURNAL Year:2002 | Volume:7 | Issue:part 1 Page(s): 53-58

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Information Journal Paper

Title

EFFECT OF LEVODOPA-B ON VISUAL ACUITY OF AMBLYOPIC EYES IN CHILDREN

Author(s)

FARVARDIN M. | MAHDIZADEH M. | | Issue Writer Certificate

Keywords

AMBLYOPIA - LEVODOPAQ2

Abstract

To evaluate the effect of Levodopa-B on visual acuity of amblyopic children and the stability of these effects after drug discontinuation. Side effects of this drug in children were also evaluated. This study was a prospective, double blind, clinical trial. 34 children (6-14 years of age), were randomly assigned to receive Levodopa-B 6mg/kg as an initial dose and then 2mg/kg three times per day for one week or placebo as control group in the same sequence. Other treatments for amblyopia were not done during this study. Corrected visual acuity (V.A.) for each eye, was measured at baseline, one hour after initial dose, after one week of treatment, and three weeks after termination of treatment. Children and their parents were questioned about the side effects of Levodopa-B. Results showed that in the treatment group, mean V.A. of amblyopic eyes improved from baseline 0.4 to 0.59 one hour after the first dose (P<0.001). It reached 0.44 after one week of treatment and to 0.45 three weeks after termination of treatment (P<0.05). In the control group, changes in mean of V.A. of amblyopic eyes were not significant (P>O.3). In the treatment group seven cases of nausea and emesis, and six cases of hyperactivity were reported one hour after first dose. These side effects subsided and were not repeated. After one week of treatment, only one case of mild depression was reported. Therefore Levodopa-B 6mg/kg per day, produces a clinical and statistically significant short- term improvement of V.A. in children with amblyopia. This improvement is stable for at least three weeks after termination of treatment. Side effects were also mild and transient.

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APA: Copy

FARVARDIN, M., & MAHDIZADEH, M.. (2002). EFFECT OF LEVODOPA-B ON VISUAL ACUITY OF AMBLYOPIC EYES IN CHILDREN. KOWSAR MEDICAL JOURNAL, 7(part 1), 53-58. SID. https://sid.ir/paper/32768/en

Vancouver: Copy

FARVARDIN M., MAHDIZADEH M.. EFFECT OF LEVODOPA-B ON VISUAL ACUITY OF AMBLYOPIC EYES IN CHILDREN. KOWSAR MEDICAL JOURNAL[Internet]. 2002;7(part 1):53-58. Available from: https://sid.ir/paper/32768/en

IEEE: Copy

M. FARVARDIN, and M. MAHDIZADEH, “EFFECT OF LEVODOPA-B ON VISUAL ACUITY OF AMBLYOPIC EYES IN CHILDREN,” KOWSAR MEDICAL JOURNAL, vol. 7, no. part 1, pp. 53–58, 2002, [Online]. Available: https://sid.ir/paper/32768/en

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