مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

IMPAIRED MEMORY AND EVIDENCE OF HISTOPATHOLOGY IN CA1 PYRAMIDAL NEURONS THROUGH INJECTION OF Aβ1-42 PEPTIDES INTO THE FRONTAL CORTICES OF RAT

Pages

  31-41

Abstract

 Introduction: Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, which has much benefited from ANIMAL MODELs to find the basics of its pathophysiology. In our previous work (Haghani, Shabani, Javan, Motamedi, & Janahmadi, 2012), a non-transgenic rat model of AD was used in electrophysiological studies. However, we did not investigate the histological aspects in the mentioned study.Methods: An AD model was developed through bilateral injection of amyloid-b peptides (Ab) into the frontal cortices. Behavioral and histological methods were used to assess alterations in the MEMORY and (ultra) structures. Furthermore, MELATONIN has been administered to assess its efficacy on this AD model.Results: Passive avoidance showed a progressive decline in the MEMORY following Ab injection.Furthermore, Nissl staining showed that Ab neurotoxicity caused shrinkage of the CA1 pyramidal neurons. Neurodegeneration was clearly evident from Fluoro-jade labeled neurons in Ab treated rats. Moreover, higher NF-κB immunoreactive CA1 pyramidal neurons were remarkably observed in Ab treated rats. Ultrastructural analysis using electron microscopy also showed the evidence of subcellular abnormalities. MELATONIN treatment in this model of AD prevented Ab- induced increased NF-κB from immunoreaction and neurodegeneration.Discussion: This study suggests that injection of Ab into the frontal cortices results in the MEMORY decline and histochemical disturbances in CA1 pyramidal neurons. Furthermore, MELATONIN can prevent several histological changes induced by Ab.

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    APA: Copy

    ESLAMIZADE, MOHAMMAD JAVAD, MADJD, ZAHRA, RASOOLIJAZI, HOMA, SAFFARZADEH, FATEMEH, PIRHAJATI, VAHID, ALIGHOLI, HADI, JANAHMADI, MAHYAR, & MEHDIZADEH, MEHDI. (2016). IMPAIRED MEMORY AND EVIDENCE OF HISTOPATHOLOGY IN CA1 PYRAMIDAL NEURONS THROUGH INJECTION OF Aβ1-42 PEPTIDES INTO THE FRONTAL CORTICES OF RAT. BASIC AND CLINICAL NEUROSCIENCE, 7(1), 31-41. SID. https://sid.ir/paper/327748/en

    Vancouver: Copy

    ESLAMIZADE MOHAMMAD JAVAD, MADJD ZAHRA, RASOOLIJAZI HOMA, SAFFARZADEH FATEMEH, PIRHAJATI VAHID, ALIGHOLI HADI, JANAHMADI MAHYAR, MEHDIZADEH MEHDI. IMPAIRED MEMORY AND EVIDENCE OF HISTOPATHOLOGY IN CA1 PYRAMIDAL NEURONS THROUGH INJECTION OF Aβ1-42 PEPTIDES INTO THE FRONTAL CORTICES OF RAT. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2016;7(1):31-41. Available from: https://sid.ir/paper/327748/en

    IEEE: Copy

    MOHAMMAD JAVAD ESLAMIZADE, ZAHRA MADJD, HOMA RASOOLIJAZI, FATEMEH SAFFARZADEH, VAHID PIRHAJATI, HADI ALIGHOLI, MAHYAR JANAHMADI, and MEHDI MEHDIZADEH, “IMPAIRED MEMORY AND EVIDENCE OF HISTOPATHOLOGY IN CA1 PYRAMIDAL NEURONS THROUGH INJECTION OF Aβ1-42 PEPTIDES INTO THE FRONTAL CORTICES OF RAT,” BASIC AND CLINICAL NEUROSCIENCE, vol. 7, no. 1, pp. 31–41, 2016, [Online]. Available: https://sid.ir/paper/327748/en

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