EFFECTS OF PAPAVER RHOEAS EXTRACT ON THE TOLERANCE TO ANALGESIC EFFECTS OF MORPHINE IN MICE

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GHOSHOUNI H.; SHAMS J.; FAGHIH MONZAVI Z.; FATEMI S.M.; SAHRAEI HEDAYAT; NOUROUZZADEH ALI

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Journal: KOWSAR MEDICAL JOURNAL Year:2007 | Volume:12 | Issue:1 Page(s): 41-47

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Title

EFFECTS OF PAPAVER RHOEAS EXTRACT ON THE TOLERANCE TO ANALGESIC EFFECTS OF MORPHINE IN MICE

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Keywords

PAPAVER RHOEASQ3

MORPHINEQ3

ANALGESIAQ3

TOLERANCEQ3

MICEQ3

Abstract

Objective: Previous studies have shown that the extract of PAPAVER RHOEAS reduces MORPHINE dependence and reward.Materials and Methods: In the present study, the effects of water-alcohol extract of PAPAVER RHOEAS on the TOLERANCE to analgesic effects of MORPHINE in MICE has been investigated using tail flick method.Results: Subcutaneous administration of MORPHINE (1, 2, 5 and 10 mg/kg) induced ANALGESIA. Reduction of analgesic in MICE pretreated with MORPHINE (50 mg/kg, twice daily; X 3 days), alone, indicated that TOLERANCE has been developed. Extract (25, 50 and 100 mg/kg, i.p.) administration, 30 min before each of three daily doses of MORPHINE attenuated the MORPHINE TOLERANCE.Conclusion: The results indicated that administration of the extract of PAPAVER RHOEAS reduces MORPHINE TOLERANCE in MICE, which may be true in human as well.

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APA: Copy

GHOSHOUNI, H., SHAMS, J., FAGHIH MONZAVI, Z., FATEMI, S.M., SAHRAEI, HEDAYAT, & NOUROUZZADEH, ALI. (2007). EFFECTS OF PAPAVER RHOEAS EXTRACT ON THE TOLERANCE TO ANALGESIC EFFECTS OF MORPHINE IN MICE. KOWSAR MEDICAL JOURNAL, 12(1), 41-47. SID. https://sid.ir/paper/32851/en

Vancouver: Copy

GHOSHOUNI H., SHAMS J., FAGHIH MONZAVI Z., FATEMI S.M., SAHRAEI HEDAYAT, NOUROUZZADEH ALI. EFFECTS OF PAPAVER RHOEAS EXTRACT ON THE TOLERANCE TO ANALGESIC EFFECTS OF MORPHINE IN MICE. KOWSAR MEDICAL JOURNAL[Internet]. 2007;12(1):41-47. Available from: https://sid.ir/paper/32851/en

IEEE: Copy

H. GHOSHOUNI, J. SHAMS, Z. FAGHIH MONZAVI, S.M. FATEMI, HEDAYAT SAHRAEI, and ALI NOUROUZZADEH, “EFFECTS OF PAPAVER RHOEAS EXTRACT ON THE TOLERANCE TO ANALGESIC EFFECTS OF MORPHINE IN MICE,” KOWSAR MEDICAL JOURNAL, vol. 12, no. 1, pp. 41–47, 2007, [Online]. Available: https://sid.ir/paper/32851/en

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