THE ROLE OF INDOMETHACIN AND THEOPHYLLINE ON KNEE JOINT DIAMETER AND VASCULAR RESPONSES

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POURABOULI IRAN; HAJIZADEH S.; NAJAFIPOUR H.; KHOUSHBATEN A.

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Paper Information

Journal: KOWSAR MEDICAL JOURNAL Year:2004 | Volume:9 | Issue:Part 2 Page(s): 101-110

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Title

THE ROLE OF INDOMETHACIN AND THEOPHYLLINE ON KNEE JOINT DIAMETER AND VASCULAR RESPONSES

Author(s)

POURABOULI IRAN | HAJIZADEH S. | NAJAFIPOUR H. | KHOUSHBATEN A. | Issue Writer Certificate

Keywords

INDOMETHACINQ3

THEOPHYLLINE CHRONIC INFLAMMATIONQ3

BLOOD FLOWQ4

KNEE JOINTQ4

Abstract

Objective . In this study the role of prostaglandins and adenosine receptors (A1/A2) on KNEE JOINT diameter and BLOOD FLOW to saphenous nerve stimulation were investigated in chronically inflamed rats. Materials and Methods . Inflammation was induced byintraarticular injection of 0.2 ml FCA and 3,7,14,21 days postinjection, KNEE JOINT diameter and BLOOD FLOW changes to proximally cut saphenous nerve stimulation were assessed using micrometer and laser Doppler flowmeter, respectively. In inflamed groups receiving INDOMETHACIN (PGs inhibitor" 3mg/kg,i.p. daily) and theophylline (A1/A2-antagonist, 50mg/kg, i.p every 12 hours) these two variables were measured too. Results. KNEE JOINT diameter measurements enhances significantly during inflammatIon (at 3-14 days) and theophylline (50 mg/kg,i.p, A1/A2- antagonist) decreased it on day 14th (18.1±3.6 v.s 7.9±1.9) but INDOMETHACIN (3 mg/kg,i.p, daily) was ineffective on it during 3 weeks. The response of articular microvasculature to nerve stimulation in normal and inflamed joints show that the constricting response to nerve stimulation was reduced significantly in inflamed group at 7,14 days especially on day 14th (-57.3±6.7 v.s -6.7±6.5) and INDOMETHACIN (3 mg /kg, i.p) enhanced constricting response 3,14 days after inflammation induction, however theophylline (50 mg/kg,i.p) reduced constricting response to nerve stimulation at 3,7 days. Conclusion . Therefore chronic inflammation has reduced constricting response of knee joint blood vessels to saphenous nerve stimulation and prostaglandins and adenosine receptors play a role in this modulation.

Cites

DOES PGE2 MEDIATEINDOMETHACIN AND THEOPHYLLINE EFFECTS ON JOINT DIAMETER AND VASCULAR RESPONSE TO SAPHENOUS NERVE STIMULATION IN CHRONICALLY INFLAMED RAT KNEE JOINT?

References

نقش پروستاگلاندین ها در تعدیل پاسخ دهی عروق زانوی موش صحرایی به فنیل افرین در التهاب مزمن

Cite

APA: Copy

POURABOULI, IRAN, HAJIZADEH, S., NAJAFIPOUR, H., & KHOUSHBATEN, A.. (2004). THE ROLE OF INDOMETHACIN AND THEOPHYLLINE ON KNEE JOINT DIAMETER AND VASCULAR RESPONSES. KOWSAR MEDICAL JOURNAL, 9(Part 2), 101-110. SID. https://sid.ir/paper/32878/en

Vancouver: Copy

POURABOULI IRAN, HAJIZADEH S., NAJAFIPOUR H., KHOUSHBATEN A.. THE ROLE OF INDOMETHACIN AND THEOPHYLLINE ON KNEE JOINT DIAMETER AND VASCULAR RESPONSES. KOWSAR MEDICAL JOURNAL[Internet]. 2004;9(Part 2):101-110. Available from: https://sid.ir/paper/32878/en

IEEE: Copy

IRAN POURABOULI, S. HAJIZADEH, H. NAJAFIPOUR, and A. KHOUSHBATEN, “THE ROLE OF INDOMETHACIN AND THEOPHYLLINE ON KNEE JOINT DIAMETER AND VASCULAR RESPONSES,” KOWSAR MEDICAL JOURNAL, vol. 9, no. Part 2, pp. 101–110, 2004, [Online]. Available: https://sid.ir/paper/32878/en

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