EFFECT OF ORAL MORPHINE CONSUMPTION ON HIPPOCAMPUS DEVELOPMENT IN WISTAR RATS EMBRYO

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RAMEZANI MINA; HAMIDI E.; HAJIZADEH MOGHADAM A.; BAHADORAN H.; SAHRAEI HEDAYAT

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Journal: KOWSAR MEDICAL JOURNAL Year:2010 | Volume:15 | Issue:1 Page(s): 11-15

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Title

EFFECT OF ORAL MORPHINE CONSUMPTION ON HIPPOCAMPUS DEVELOPMENT IN WISTAR RATS EMBRYO

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Keywords

MORPHINEQ3

HIPPOCAMPUSQ3

EMBRYOQ3

RATQ3

Abstract

Aims: In the present study, the effect of oral MORPHINE consumption on HIPPOCAMPUS development in Wistar RAT EMBRYOs of weight range of 250-300g was investigated.Materials & Methods: 12 pregnant Wistar RATs with weight range of 250-300g were fed daily with 0.05 g MORPHINE solution in water until day 19 of pregnancy. Then, pregnant RATs went under surgery and the EMBRYO was removed with the uterus and was fixed in formalin 10% for 60 days. Then, using some stages such as processing, cutting and staining, the samples were provided and evaluated using light microscope and MOTIC software.Results: Diameter of inner, middle and an outer layer of HIPPOCAMPUS reduced in the experimental group comparing to control group; while, the cell number increased in experimental group comparing to control group but their cell size was considerably reduced.Conclusion: Oral MORPHINE consumption may delay HIPPOCAMPUS development in Wistar RAT EMBRYOs, which it is seen in cell increment of this area to its different layers and layer diameter decrement of each layer.

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APA: Copy

RAMEZANI, MINA, HAMIDI, E., HAJIZADEH MOGHADAM, A., BAHADORAN, H., & SAHRAEI, HEDAYAT. (2010). EFFECT OF ORAL MORPHINE CONSUMPTION ON HIPPOCAMPUS DEVELOPMENT IN WISTAR RATS EMBRYO. KOWSAR MEDICAL JOURNAL, 15(1), 11-15. SID. https://sid.ir/paper/32905/en

Vancouver: Copy

RAMEZANI MINA, HAMIDI E., HAJIZADEH MOGHADAM A., BAHADORAN H., SAHRAEI HEDAYAT. EFFECT OF ORAL MORPHINE CONSUMPTION ON HIPPOCAMPUS DEVELOPMENT IN WISTAR RATS EMBRYO. KOWSAR MEDICAL JOURNAL[Internet]. 2010;15(1):11-15. Available from: https://sid.ir/paper/32905/en

IEEE: Copy

MINA RAMEZANI, E. HAMIDI, A. HAJIZADEH MOGHADAM, H. BAHADORAN, and HEDAYAT SAHRAEI, “EFFECT OF ORAL MORPHINE CONSUMPTION ON HIPPOCAMPUS DEVELOPMENT IN WISTAR RATS EMBRYO,” KOWSAR MEDICAL JOURNAL, vol. 15, no. 1, pp. 11–15, 2010, [Online]. Available: https://sid.ir/paper/32905/en

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