THE EFFECT OF INTRAENTORHINAL INJECTION OF SELECTIVE AL RECEPTOR AGONIST ON PIRIFORM CORTEX KINDLED SEIZURES IN RATS

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HOSSEINMARDI N.; FATH ELAHI Y.; SHAHABI P.; REZVANI M.E.; NAMVAR S.; PALIZVAN M.R.; MIRNAJAFIZADEH S.J.

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Journal: KOWSAR MEDICAL JOURNAL Year:2005 | Volume:10 | Issue:2 Page(s): 103-110

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Title

THE EFFECT OF INTRAENTORHINAL INJECTION OF SELECTIVE AL RECEPTOR AGONIST ON PIRIFORM CORTEX KINDLED SEIZURES IN RATS

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Keywords

SEIZUREQ3

ELECTRICAL KINDLINGQ4

PIRIFOFFIL CORTEXQ3

ENTORHINAL CORTEXQ4

ADENOSINE A1 RECEPTORSQ4

Abstract

Objective: In this research the role of ADENOSINE A1 RECEPTORS of the ENTORHINAL CORTEX on piriform cortex- kindled SEIZUREs was investigated. Materials and Methods: Animals were kindled by daily electrical stimulation of the piriform cortex. Then N6-Cyclohexyladenosine (CRA), an adenosine A1receptor agonist, at concentrations of 1,10 and 100 µM and 1,3-dimethyl-8 cyclopenthylxanthine (CPT), an adenosine A1 receptor antagonist, at concentrations of 50 and 100 µM were injected into the ENTORHINAL CORTEX. Animals were stimulated 5 min after drug injection and SEIZURE parameters were recorded. Also in another group of animals, CPT (50 µM) was injected 5 min before CRA (100 µM). Results: CRA at a concentration of 100 µM decreased the after discharge duration (ADD), stage 5 duration (S5D), and SEIZURE duration (SD), and increased the latency to stage 4 of the SEIZURE (S4L) significantly. CRA at a concentration of 10 µM decreased only SD and increased S4L significantly. On the other hand bilateral microinjection of CPT into the ENTORHINAL CORTEX at a concentration of 100 µM increased ADD, S5D, and SD, and reduced S4L significantly. Pretreatment of animals with CPT (50 µM), 5 min before CRA (100 µM), reduced the effect of CRA on SEIZURE parameters. Conclusion: These results suggest that ADENOSINE A1 RECEPTORS activity in the ENTORHINAL CORTEX reduces piriform cortex kindled SEIZUREs.

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APA: Copy

HOSSEINMARDI, N., FATH ELAHI, Y., SHAHABI, P., REZVANI, M.E., NAMVAR, S., PALIZVAN, M.R., & MIRNAJAFIZADEH, S.J.. (2005). THE EFFECT OF INTRAENTORHINAL INJECTION OF SELECTIVE AL RECEPTOR AGONIST ON PIRIFORM CORTEX KINDLED SEIZURES IN RATS. KOWSAR MEDICAL JOURNAL, 10(2), 103-110. SID. https://sid.ir/paper/32960/en

Vancouver: Copy

HOSSEINMARDI N., FATH ELAHI Y., SHAHABI P., REZVANI M.E., NAMVAR S., PALIZVAN M.R., MIRNAJAFIZADEH S.J.. THE EFFECT OF INTRAENTORHINAL INJECTION OF SELECTIVE AL RECEPTOR AGONIST ON PIRIFORM CORTEX KINDLED SEIZURES IN RATS. KOWSAR MEDICAL JOURNAL[Internet]. 2005;10(2):103-110. Available from: https://sid.ir/paper/32960/en

IEEE: Copy

N. HOSSEINMARDI, Y. FATH ELAHI, P. SHAHABI, M.E. REZVANI, S. NAMVAR, M.R. PALIZVAN, and S.J. MIRNAJAFIZADEH, “THE EFFECT OF INTRAENTORHINAL INJECTION OF SELECTIVE AL RECEPTOR AGONIST ON PIRIFORM CORTEX KINDLED SEIZURES IN RATS,” KOWSAR MEDICAL JOURNAL, vol. 10, no. 2, pp. 103–110, 2005, [Online]. Available: https://sid.ir/paper/32960/en

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