ROLE OF ADENOSINE A2A RECEPTORS OF HIPPOCAMPUS CA1 REGIONS ON PIRIFORM CORTEX KINDLED RATS

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ZERAATI M.; FATH ELAHI Y.; REZVANI E.; MIRNAJAFIZADEH S.J.; HOSSEINMARDI N.

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Journal: KOWSAR MEDICAL JOURNAL Year:2005 | Volume:10 | Issue:3 Page(s): 167-173

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Title

ROLE OF ADENOSINE A2A RECEPTORS OF HIPPOCAMPUS CA1 REGIONS ON PIRIFORM CORTEX KINDLED RATS

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Keywords

SEIZUREQ3

PIRIFORM CORTEXQ4

HIPPOCAMPUSQ3

ADENOSINE A2A RECEPTORSQ4

RATQ3

Abstract

Objective: The effect of activity of adenosine A1A receptors of the CA1 region of the HIPPOCAMPUS on PIRIFORM CORTEX–kindled SEIZUREs was investigated in RATs. Material and Methods: After electrical kindling of animals, CGS21680hydrochloride (CGS), an ADENOSINE A2A RECEPTORS agonist, at doses of 10, 200 and 500 μM and ZM241385 (ZM), an adenosine A2A receptor antagonist, at doses of 50 and 100 μM were microinjected into the CA1 region of the HIPPOCAMPUS. The animals were stimulated 15 min after drug injection. In each case, 15 h prior to the drug injection, animals received ACSF (drug solvent) and were stimulated in the same way and results were recorded as control values. At 6 least 6 RATs were used in each group. Results: Bilateral microinjection of CGS, at doses of 200 and 500 μM into the hippocampal CA1 region increased the after discharge duration (ADD) and had no effects on S4L, S5D and SD. Bilateral microinjection of ZM had no effect on SEIZURE parameters. Pretreatment of animals with ZM (50 μM) before CGS (200 μM), prevented the effect of CGS on SEIZURE parameters significantly. Conclusion: Thus, it may be suggested that the ADENOSINE A2A RECEPTORS of the hippocampal CA1 region may have a facilitatory role in SEIZURE activities elicited from the PIRIFORM CORTEX.

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APA: Copy

ZERAATI, M., FATH ELAHI, Y., REZVANI, E., MIRNAJAFIZADEH, S.J., & HOSSEINMARDI, N.. (2005). ROLE OF ADENOSINE A2A RECEPTORS OF HIPPOCAMPUS CA1 REGIONS ON PIRIFORM CORTEX KINDLED RATS. KOWSAR MEDICAL JOURNAL, 10(3), 167-173. SID. https://sid.ir/paper/32967/en

Vancouver: Copy

ZERAATI M., FATH ELAHI Y., REZVANI E., MIRNAJAFIZADEH S.J., HOSSEINMARDI N.. ROLE OF ADENOSINE A2A RECEPTORS OF HIPPOCAMPUS CA1 REGIONS ON PIRIFORM CORTEX KINDLED RATS. KOWSAR MEDICAL JOURNAL[Internet]. 2005;10(3):167-173. Available from: https://sid.ir/paper/32967/en

IEEE: Copy

M. ZERAATI, Y. FATH ELAHI, E. REZVANI, S.J. MIRNAJAFIZADEH, and N. HOSSEINMARDI, “ROLE OF ADENOSINE A2A RECEPTORS OF HIPPOCAMPUS CA1 REGIONS ON PIRIFORM CORTEX KINDLED RATS,” KOWSAR MEDICAL JOURNAL, vol. 10, no. 3, pp. 167–173, 2005, [Online]. Available: https://sid.ir/paper/32967/en

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