EFFECT OF GANODERMA LUCIDUM (REISHI) ON CELL VIABILITY AND NITRIC OXIDE PRODUCTION

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AHMADI KAZEM; RIAZIPOUR M.

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Journal: KOWSAR MEDICAL JOURNAL Year:2008 | Volume:12 | Issue:4 Page(s): 281-287

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Information Journal Paper

Title

EFFECT OF GANODERMA LUCIDUM (REISHI) ON CELL VIABILITY AND NITRIC OXIDE PRODUCTION

Author(s)

AHMADI KAZEM | RIAZIPOUR M. | Issue Writer Certificate

Keywords

GANODERMA LUCIDUMQ2

CELL VIABILITYQ3

NITRIC OXIDEQ3

Abstract

Background: Reishi extract is an herbal mushroom preparation which been used worldwide for the prevention and treatment of various cancers. The current study was designed to evaluate the effect of Reishi on CELL VIABILITY and NITRIC OXIDE (NO) release by mice peritoneal macrophages (mF). Materials and Methods: Mice were anesthetized and had their macrophages collected. The macrophages were washed three times, counted and plated out at 1x106 cells/well in 24 wells plate. Cells were incubated at 37°C and 5% CO2 for 24h in the presence of different concentrations of G. lucidum. After that, Supernatant was collected for NO assay (NO2 was measured as an indicator of NO) and CELL VIABILITY was checked by trepan Blue dye. Results: The Results showed that, G. lucidum at concentration between 5 to 160 mg/ml induced cell death between 5-10 percent, while at concentrations between 320 mg to 640 mg induced cell death between 25% to 28%(P<0.001). The maximum NO was released in response to 320 m/ml of G. lucidum. The level of NO production in response to all concentrations of G. lucidum was significantly different comparing to control group (p<0.005, p<0.001). Conclusion: Taken together, it can be concluded that G. lucidum at concentrations among 5 mg to 160 mg has immunomodulatory effect on peritoneal mFin term of NO production. The enhancement of cell death in response to higher concentration of G. lucidum also might be due to cytotoxic effects of NITRIC OXIDE on own cell producer, but not exactly as a result of cytotoxic effect of G. lucidum.

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APA: Copy

AHMADI, KAZEM, & RIAZIPOUR, M.. (2008). EFFECT OF GANODERMA LUCIDUM (REISHI) ON CELL VIABILITY AND NITRIC OXIDE PRODUCTION. KOWSAR MEDICAL JOURNAL, 12(4), 281-287. SID. https://sid.ir/paper/33026/en

Vancouver: Copy

AHMADI KAZEM, RIAZIPOUR M.. EFFECT OF GANODERMA LUCIDUM (REISHI) ON CELL VIABILITY AND NITRIC OXIDE PRODUCTION. KOWSAR MEDICAL JOURNAL[Internet]. 2008;12(4):281-287. Available from: https://sid.ir/paper/33026/en

IEEE: Copy

KAZEM AHMADI, and M. RIAZIPOUR, “EFFECT OF GANODERMA LUCIDUM (REISHI) ON CELL VIABILITY AND NITRIC OXIDE PRODUCTION,” KOWSAR MEDICAL JOURNAL, vol. 12, no. 4, pp. 281–287, 2008, [Online]. Available: https://sid.ir/paper/33026/en

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