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Information Journal Paper

Title

FLUOXETINE IMPROVES THE EFFECT OF LEVODOPA ON 6-HYDROXY DOPAMINE-INDUCED MOTOR IMPAIRMENTS IN RATS

Pages

  149-155

Keywords

5-HT1A RECEPTOR 
RAT 

Abstract

 Purpose: Long term L-DOPA therapy in Parkinson’s disease is associated with troublesome motor fluctuations such as L -DOPA Induced dyskinesia and wearing off effect. Our recent study showed that activation of 5-HT1A receptors could improve the anti-cataleptic effect of L-DOPA in parkinsonian RATs. In this study we investigated the effect of FLUOXETINE on anti-parkinsonian effect of L-DOPA in 6-hydroxydopamine (6-OHDA) -lesioned RATs.Methods: CATALEPSY and motor incoordination were induced by unilateral injection of 6-OHDA (8 mg/2 ml/rat) into the central region of the sabstantia nigra pars compacta (SNc). After 3 weeks as a recovery period, these RATs injected intraperitoneally (i.p.) L-DOPA (15 mg/kg) twice daily for 20 consecutive days, and anti-parkinsonian effect of L-DOPA was investigated by bar-test and rotarod on days 5, 10, 15 and 20.Results: The results showed that L-DOPA is able to improve motor coordination in rotarod only until day 15 and these effects of L-DOPA were abolished on the day 20. On day 21, RATs were co-injected with FLUOXETINE (0.1, 0.5 and 1mg/kg, i.p.) and L-DOPA (15 mg/kg, i.p.). FLUOXETINE increased anti-cataleptic effect of L-DOPA at the dose of 1 mg/kg, while FLUOXETINE had not any impact on the effect of L-DOPA in rotarod test. The effect of FLUOXETINE (1 mg/kg, i.p.) on anti-cataleptic effect of L-DOPA (15 mg/kg, i.p.) was reversed by 1- (2-methoxyphenyl) -4- (4-phthalimidobutyl) piperazine hydrobromide (NAN-190; 0.5 mg/kg, i.p.), as a 5-HT1A receptor antagonist.Conclusion: According to the results, it may be concluded that FLUOXETINE improves 6-OHDA-induced CATALEPSY and MOTOR IMBALANCE in L-DOPA- treated RATs through activation of 5-HT1A. Further studies should be designed to clarify the precise mechanism of interaction between 5-HT1A and dopaminergic neurons.

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    APA: Copy

    MAHMOUDI, JAVAD, MOHAJJEL NAYEBI, ALIREZA, REYHANI RAD, SIAMAK, & SAMINI, MORTEZA. (2012). FLUOXETINE IMPROVES THE EFFECT OF LEVODOPA ON 6-HYDROXY DOPAMINE-INDUCED MOTOR IMPAIRMENTS IN RATS. ADVANCED PHARMACEUTICAL BULLETIN, 2(2), 149-155. SID. https://sid.ir/paper/331658/en

    Vancouver: Copy

    MAHMOUDI JAVAD, MOHAJJEL NAYEBI ALIREZA, REYHANI RAD SIAMAK, SAMINI MORTEZA. FLUOXETINE IMPROVES THE EFFECT OF LEVODOPA ON 6-HYDROXY DOPAMINE-INDUCED MOTOR IMPAIRMENTS IN RATS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2012;2(2):149-155. Available from: https://sid.ir/paper/331658/en

    IEEE: Copy

    JAVAD MAHMOUDI, ALIREZA MOHAJJEL NAYEBI, SIAMAK REYHANI RAD, and MORTEZA SAMINI, “FLUOXETINE IMPROVES THE EFFECT OF LEVODOPA ON 6-HYDROXY DOPAMINE-INDUCED MOTOR IMPAIRMENTS IN RATS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 2, no. 2, pp. 149–155, 2012, [Online]. Available: https://sid.ir/paper/331658/en

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