مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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1

Information Journal Paper

Title

COMPARISON OF IN VITRO ACTIVITY OF DORIPENEM VERSUS OLD CARBAPENEMS AGAINST PSEUDOMONAS AERUGINOSA CLINICAL ISOLATES FROM BOTH CF AND BURN PATIENTS

Pages

  121-125

Abstract

 Purpose: The antimicrobial activity of DORIPENEM in comparison of IMIPENEM, meropenem and ertapenem among PSEUDOMONAS AERUGINOSA isolated from BURN and CYSTIC FIBROSIS (CF) patients were determined.Methods: Metallo-b-lactamase (MBL) genes in IMIPENEM non susceptible P. aeruginosa isolates were detected using PCR method. The in vitro susceptibilities of DORIPENEM, IMIPENEM, meropenem and ertapenem were determined by Etests. MIC50 and MIC90 for corresponding antibiotics were determined individually in BURN and CF isolates.Results: Among isolates which were resistant to IMIPENEM, 16 isolates were positive for the bla IMP gene. All isolates had no bla VIM gene. All MBL producing isolates were excluded. MIC50/MIC90 of DORIPENEM in CF and BURN isolates were 0.75/>32 and>32/>32 mg/L respectively. The corresponding values for IMIPENEM in CF and BURN isolates were 2/>32 and>32/>32 mg/L, respectively.Conclusion: The susceptibility rate of DORIPENEM is higher than that of IMIPENEM and meropenem among P.aeruginosa isolated from CF patients, whereas, there is no difference between the efficiency of DORIPENEM and old carbapenems in non MBL producing P.aeruginosa isolates in BURN patients.

Cites

References

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    • Cite

    APA: Copy

    HOJABRI, ZOYA, AHANGARZADEH REZAEI, MOHAMMAD, NAHAEE, MOHAMMAD REZA, SORUSH, MOHAMMAD HOSSEIN, GHOJAZADEH, MORTEZA, PIRZADE, TAHERE, DAVODI, MOSTAFA, GHAZI, MONA, BIGVERDI, REZA, PAJAND, OMID, & AGHAZADEH, MOHAMMAD. (2013). COMPARISON OF IN VITRO ACTIVITY OF DORIPENEM VERSUS OLD CARBAPENEMS AGAINST PSEUDOMONAS AERUGINOSA CLINICAL ISOLATES FROM BOTH CF AND BURN PATIENTS. ADVANCED PHARMACEUTICAL BULLETIN, 3(1), 121-125. SID. https://sid.ir/paper/331686/en

    Vancouver: Copy

    HOJABRI ZOYA, AHANGARZADEH REZAEI MOHAMMAD, NAHAEE MOHAMMAD REZA, SORUSH MOHAMMAD HOSSEIN, GHOJAZADEH MORTEZA, PIRZADE TAHERE, DAVODI MOSTAFA, GHAZI MONA, BIGVERDI REZA, PAJAND OMID, AGHAZADEH MOHAMMAD. COMPARISON OF IN VITRO ACTIVITY OF DORIPENEM VERSUS OLD CARBAPENEMS AGAINST PSEUDOMONAS AERUGINOSA CLINICAL ISOLATES FROM BOTH CF AND BURN PATIENTS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(1):121-125. Available from: https://sid.ir/paper/331686/en

    IEEE: Copy

    ZOYA HOJABRI, MOHAMMAD AHANGARZADEH REZAEI, MOHAMMAD REZA NAHAEE, MOHAMMAD HOSSEIN SORUSH, MORTEZA GHOJAZADEH, TAHERE PIRZADE, MOSTAFA DAVODI, MONA GHAZI, REZA BIGVERDI, OMID PAJAND, and MOHAMMAD AGHAZADEH, “COMPARISON OF IN VITRO ACTIVITY OF DORIPENEM VERSUS OLD CARBAPENEMS AGAINST PSEUDOMONAS AERUGINOSA CLINICAL ISOLATES FROM BOTH CF AND BURN PATIENTS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 1, pp. 121–125, 2013, [Online]. Available: https://sid.ir/paper/331686/en

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