مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

272
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

616
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

FORMULATION, CHARACTERIZATION AND PHYSICOCHEMICAL EVALUATION OF POTASSIUM CITRATE EFFERVESCENT TABLETS

Pages

  217-225

Abstract

 Purpose: The aim of this study was to design and formulation of POTASSIUM CITRATE effervescent tablet for reduction of calcium oxalate and urate kidney stones in patients suffering from kidney stones.Methods: In this study, 13 formulations were prepared from POTASSIUM CITRATE and effervescent base in different concentration. The flowability of powders and granules was studied. Then EFFERVESCENT TABLETS were prepared by direct compression, fusion and WET GRANULATION METHODs. The prepared tablets were evaluated for hardness, friability, effervescent time, pH, content uniformity. To amend taste of formulations, different flavoring agents were used and then panel test was done by using Latin Square method by 30 volunteers.Results: Formulations obtained from direct compression and FUSION METHODs had good flow but low hardness. Wet granulation improves flowability and other physicochemical properties such as acceptable hardness, effervescence time £3 minutes, pH<6, friability<1%, water percentage<0.5% and accurate content uniformity. In panel test, both of combination flavors; (orange - lemon) and (strawberry - raspberry) had good acceptability.Conclusion: The prepared tablets by WET GRANULATION METHOD using PVP solution had more tablet hardness. It is a reproducible process and suitable to produce granules that are compressed into EFFERVESCENT TABLETS due to larger agglomerates.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    ASLANI, ABOU ALFAZL, & FATTAHI, FATEMEH. (2013). FORMULATION, CHARACTERIZATION AND PHYSICOCHEMICAL EVALUATION OF POTASSIUM CITRATE EFFERVESCENT TABLETS. ADVANCED PHARMACEUTICAL BULLETIN, 3(1), 217-225. SID. https://sid.ir/paper/331689/en

    Vancouver: Copy

    ASLANI ABOU ALFAZL, FATTAHI FATEMEH. FORMULATION, CHARACTERIZATION AND PHYSICOCHEMICAL EVALUATION OF POTASSIUM CITRATE EFFERVESCENT TABLETS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(1):217-225. Available from: https://sid.ir/paper/331689/en

    IEEE: Copy

    ABOU ALFAZL ASLANI, and FATEMEH FATTAHI, “FORMULATION, CHARACTERIZATION AND PHYSICOCHEMICAL EVALUATION OF POTASSIUM CITRATE EFFERVESCENT TABLETS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 1, pp. 217–225, 2013, [Online]. Available: https://sid.ir/paper/331689/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button