THERMOANALYTICAL INVESTIGATION OF TERAZOSIN HYDROCHLORIDE

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KAMAL ATTIA ALI; MOHAMED ABDEL MOETY MONA

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Journal Paper

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Journal: Advanced Pharmaceutical Bulletin Year:2013 | Volume:3 | Issue:1 Page(s): 147-152

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Information Journal Paper

Title

THERMOANALYTICAL INVESTIGATION OF TERAZOSIN HYDROCHLORIDE

Author(s)

KAMAL ATTIA ALI | MOHAMED ABDEL MOETY MONA | Issue Writer Certificate

Keywords

TERAZOSIN HYDROCHLORIDE

THERMAL ANALYSIS

DIFFERENTIAL SCANNING CALORIMETRY

PURITY

Abstract

Purpose: THERMAL ANALYSIS (TGA, DTG and DTA) and DIFFERENTIAL SCANNING CALORIMETRY (DSC) have been used to study the thermal behavior of TERAZOSIN HYDROCHLORIDE (TER). Methods: Thermogravimetric analysis (TGA/DTG), differential THERMAL ANALYSIS (DTA) and DIFFERENTIAL SCANNING CALORIMETRY (DSC) were used to determine the thermal behavior and PURITY of the used drug. Thermodynamic parameters such as activation energy (E*), enthalpy (DH*), entropy (DS*) and Gibbs free energy change of the decomposition (DG*) were calculated using different kinetic models.Results: The PURITY of the used drug was determined by DIFFERENTIAL SCANNING CALORIMETRY (99.97%) and specialized official method (99.85%) indicating to satisfactory values of the degree of PURITY. THERMAL ANALYSIS technique gave satisfactory results to obtain quality control parameters such as melting point (273oC), water content (7.49%) and ash content (zero) in comparison to what were obtained using official method: (272oC), (8.0%) and (0.02%) for melting point, water content and ash content, respectively.Conclusion: THERMAL ANALYSIS justifies its application in quality control of pharmaceutical compounds due to its simplicity, sensitivity and low operational costs. DSC data indicated that the degree of PURITY of TERAZOSIN HYDROCHLORIDE is similar to that found by official method.

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APA: Copy

KAMAL ATTIA, ALI, & MOHAMED ABDEL MOETY, MONA. (2013). THERMOANALYTICAL INVESTIGATION OF TERAZOSIN HYDROCHLORIDE. ADVANCED PHARMACEUTICAL BULLETIN, 3(1), 147-152. SID. https://sid.ir/paper/331706/en

Vancouver: Copy

KAMAL ATTIA ALI, MOHAMED ABDEL MOETY MONA. THERMOANALYTICAL INVESTIGATION OF TERAZOSIN HYDROCHLORIDE. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(1):147-152. Available from: https://sid.ir/paper/331706/en

IEEE: Copy

ALI KAMAL ATTIA, and MONA MOHAMED ABDEL MOETY, “THERMOANALYTICAL INVESTIGATION OF TERAZOSIN HYDROCHLORIDE,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 1, pp. 147–152, 2013, [Online]. Available: https://sid.ir/paper/331706/en

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