مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

263
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

129
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

THE EFFECT OF CHRONIC ADMINISTRATION OF BUSPIRONE ON 6-HYDROXYDOPAMINE-INDUCED CATALEPSY IN RATS

Pages

  127-131

Abstract

 Purpose: Several evidences show that serotonergic neurons play a role in the regulation of movements executed by the basal ganglia. Recently we have reported that single dose of BUSPIRONE improved 6-HYDROXYDOPAMINE (6-OHDA) and haloperidol-induced CATALEPSY. This study is aimed to investigate effect of CHRONIC intraperitoneal (i.p.) administration of BUSPIRONE on 6-OHDA-induced CATALEPSY in male Wistar RATs.Methods: CATALEPSY was induced by unilateral infusion of 6-OHDA (8 mg/2 ml/rat) into the central region of the SNc and was assayed by the bar-test method 5, 60, 120 and 180 min after drugs administration in 10th day. The effect of BUSPIRONE (0.5, 1 and 2 mg/kg, i.p. for 10 days) was assessed in 6-OHDA-lesioned RATs.Results: The results showed that CHRONIC injection of BUSPIRONE (0.5, 1 and 2 mg/kg, i.p. for 10 days) decreased CATALEPSY when compared with the control group. The best anticataleptic effect was observed at the dose of 1 mg/kg. The CATALEPSY-improving effect of BUSPIRONE was reversed by 1-(2-methoxyphenyl)- 4-[4-(2-phthalimido) butyl]piperazine hydrobromide (NAN-190), 0.5 mg/kg, i.p., as a 5-HT1A receptor antagonist.Conclusion: Our study indicates that CHRONIC administration of BUSPIRONE improves CATALEPSY in a 6-OHDA-induced animal model of parkinson’s disease (PD). We also suggest that BUSPIRONE may be used as an adjuvant therapy to increase effectiveness of antiparkinsonian drugs. In order to prove this hypothesis, further clinical studies should be done.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    SHARIFI, HAMDOLAH, MOHAJJEL NAYEBI, ALIREZA, & FARAJNIA, SAFAR. (2012). THE EFFECT OF CHRONIC ADMINISTRATION OF BUSPIRONE ON 6-HYDROXYDOPAMINE-INDUCED CATALEPSY IN RATS. ADVANCED PHARMACEUTICAL BULLETIN, 2(1), 127-131. SID. https://sid.ir/paper/331714/en

    Vancouver: Copy

    SHARIFI HAMDOLAH, MOHAJJEL NAYEBI ALIREZA, FARAJNIA SAFAR. THE EFFECT OF CHRONIC ADMINISTRATION OF BUSPIRONE ON 6-HYDROXYDOPAMINE-INDUCED CATALEPSY IN RATS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2012;2(1):127-131. Available from: https://sid.ir/paper/331714/en

    IEEE: Copy

    HAMDOLAH SHARIFI, ALIREZA MOHAJJEL NAYEBI, and SAFAR FARAJNIA, “THE EFFECT OF CHRONIC ADMINISTRATION OF BUSPIRONE ON 6-HYDROXYDOPAMINE-INDUCED CATALEPSY IN RATS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 2, no. 1, pp. 127–131, 2012, [Online]. Available: https://sid.ir/paper/331714/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button