APPLICATION OF LACTOBIONIC ACID AND NONIONIC SURFACTANTS AS SOLUBILIZING AGENTS FOR PARENTERAL FORMULATION OF CLARITHROMYCIN

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ZAKERI MILANI PARVIN; MOUSAVIAN FATHI NIAZ; GHANBARZADEH SAEED; ZARRINTAN MOHAMMAD HOSEIN; VALIZADEH HADI

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Journal: Advanced Pharmaceutical Bulletin Year:2012 | Volume:2 | Issue:1 Page(s): 37-42

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Title

APPLICATION OF LACTOBIONIC ACID AND NONIONIC SURFACTANTS AS SOLUBILIZING AGENTS FOR PARENTERAL FORMULATION OF CLARITHROMYCIN

Author(s)

Keywords

CLARITHROMYCIN

LACTOBIONIC ACID

NONIONIC SURFACTANTS

SOLUBILITY

PARENTERAL

Abstract

Purpose: The purpose of this paper is to enhance the SOLUBILITY of CLARITHROMYCIN (CLR) using NONIONIC SURFACTANTS and some type of acids for preparation of the new formulations.Methods: Myrj 52 and chremophor (2.5 and 5% w/v) were used in two concentrations. To investigate SOLUBILITY, the formulations were shaken for 48 hours at room temperature. For stability test, lyophilized samples were maintained in refrigerator at 4oC, and in oven at 40oC. Drug analysis was performed by reverse phase high performance liquid chromatography (HPLC) with ultraviolet detection.Results: SOLUBILITY tests indicated that LACTOBIONIC ACID was the most effective to increase CLARITHROMYCIN SOLUBILITY and chremophor showed higher enhancing effect than myrj 52 on CLR SOLUBILITY. The stability tests results also confirmed that shelf-lives of all formulations have been the equivalent to 24 months.Conclusion: On the whole, formulations described in this article may be very suitable for industrial-scale manufacturing and clinical application.

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APA: Copy

ZAKERI MILANI, PARVIN, MOUSAVIAN FATHI, NIAZ, GHANBARZADEH, SAEED, ZARRINTAN, MOHAMMAD HOSEIN, & VALIZADEH, HADI. (2012). APPLICATION OF LACTOBIONIC ACID AND NONIONIC SURFACTANTS AS SOLUBILIZING AGENTS FOR PARENTERAL FORMULATION OF CLARITHROMYCIN. ADVANCED PHARMACEUTICAL BULLETIN, 2(1), 37-42. SID. https://sid.ir/paper/331726/en

Vancouver: Copy

ZAKERI MILANI PARVIN, MOUSAVIAN FATHI NIAZ, GHANBARZADEH SAEED, ZARRINTAN MOHAMMAD HOSEIN, VALIZADEH HADI. APPLICATION OF LACTOBIONIC ACID AND NONIONIC SURFACTANTS AS SOLUBILIZING AGENTS FOR PARENTERAL FORMULATION OF CLARITHROMYCIN. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2012;2(1):37-42. Available from: https://sid.ir/paper/331726/en

IEEE: Copy

PARVIN ZAKERI MILANI, NIAZ MOUSAVIAN FATHI, SAEED GHANBARZADEH, MOHAMMAD HOSEIN ZARRINTAN, and HADI VALIZADEH, “APPLICATION OF LACTOBIONIC ACID AND NONIONIC SURFACTANTS AS SOLUBILIZING AGENTS FOR PARENTERAL FORMULATION OF CLARITHROMYCIN,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 2, no. 1, pp. 37–42, 2012, [Online]. Available: https://sid.ir/paper/331726/en

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