مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ANTIPROLIFERATIVE EFFECT OF GYNURA PROCUMBENS (LOUR.) MERR. LEAVES ETANOLIC EXTRACT ON 7, 12-DIMETHYLBENZ (A) ANTRACENE INDUCED MALE RAT LIVER

Pages

  99-106

Abstract

 Purpose: The leaves of GYNURA PROCUMBENS (Lour.) Merr. has been traditionally used as anticancer. Ethanolic extract of G. procumbens leaves (EGP) showed cytotoxic activity and anticancer activity in animal cancer model. This study was conducted to observe antiproliferative effect using male rat’s liver cells induced by 7, 12-dimethylbenz(a)antracene (DMBA).Methods: Forty days old Sprague Dawley male rats were divided into 4 groups, (1) 0.5 % CMC Na, (2) 20 mg/kg BW DMBA p.o ten times in three weeks, (3) DMBA+300 mg/kg BW of EGP, and (4) DMBA+750 mg/kg BW of EGP. The extract was dissolved into 0.5 % CMC-and administered daily per oral one week before, during and terminated 1 week after the DMBA induction. After sixthteen week experiment, rat livers were sectioned and stained with Haematoxyllene and Eosin (H&E) and AGNOR.Results: Histopatology profile showed no primary liver tumor on DMBA group. mAgNOR value of DMBA+300 mg/kg BW EGP showed significant antiproliferative effect compared to DMBA group.Conclusion: Ethanolic extract of G. procumbens leaves showed antiproliferative activity on male rats liver induced by DMBA.

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    APA: Copy

    NISA, FITHRIYATUN, HERMAWAN, ADAM, MURWANTI, RETNO, & MEIYANTO, EDY. (2012). ANTIPROLIFERATIVE EFFECT OF GYNURA PROCUMBENS (LOUR.) MERR. LEAVES ETANOLIC EXTRACT ON 7, 12-DIMETHYLBENZ (A) ANTRACENE INDUCED MALE RAT LIVER. ADVANCED PHARMACEUTICAL BULLETIN, 2(1), 99-106. SID. https://sid.ir/paper/331728/en

    Vancouver: Copy

    NISA FITHRIYATUN, HERMAWAN ADAM, MURWANTI RETNO, MEIYANTO EDY. ANTIPROLIFERATIVE EFFECT OF GYNURA PROCUMBENS (LOUR.) MERR. LEAVES ETANOLIC EXTRACT ON 7, 12-DIMETHYLBENZ (A) ANTRACENE INDUCED MALE RAT LIVER. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2012;2(1):99-106. Available from: https://sid.ir/paper/331728/en

    IEEE: Copy

    FITHRIYATUN NISA, ADAM HERMAWAN, RETNO MURWANTI, and EDY MEIYANTO, “ANTIPROLIFERATIVE EFFECT OF GYNURA PROCUMBENS (LOUR.) MERR. LEAVES ETANOLIC EXTRACT ON 7, 12-DIMETHYLBENZ (A) ANTRACENE INDUCED MALE RAT LIVER,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 2, no. 1, pp. 99–106, 2012, [Online]. Available: https://sid.ir/paper/331728/en

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