SYNERGIC ANTIBACTERIAL EFFECT OF CURCUMIN WITH AMPICILLIN; FREE DRUG SOLUTIONS IN COMPARISON WITH SLN DISPERSIONS

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ALIHOSSEINI FAEZEH; AZARMI SHIRZAD; GHAFFARI SOLMAZ; HAGHIGHAT SETAREH; REZAYAT SORKHABADI SEYED MAHDI

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Journal: Advanced Pharmaceutical Bulletin Year:2016 | Volume:6 | Issue:3 Page(s): 461-465

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Title

SYNERGIC ANTIBACTERIAL EFFECT OF CURCUMIN WITH AMPICILLIN; FREE DRUG SOLUTIONS IN COMPARISON WITH SLN DISPERSIONS

Author(s)

Keywords

SOLID LIPID NANOPARTICLES

CURCUMIN

SYNERGY

AMPICILLIN

Abstract

Purpose: This study was designed to investigate benefit of using nanotechnology on increasing of synergic antibacterial effect of natural and chemical antibacterial agents.Methods: At first the MIC and MBC of CURCUMIN and AMPICILLIN as selected antibacterial agents was determined, after that SOLID LIPID NANOPARTICLES (SLNs) of each active ingredients as well as CURCUMIN-Ampicillin loaded SLNs were prepared using high pressure homogenization technique. Characterization of prepared SLNs was done, then MIC, MBC and contact killing time were investigated for CURCUMIN-Ampicillin loaded SLNs in comparison with free CURCUMIN and AMPICILLIN solutions as well as AMPICILLIN and CURCUMIN SLNs.Results: Based on results nanoparticles with the size of 150 nm show much more decreased MIC and MBC when AMPICILLIN and CURCUMIN were loaded together on SLNs than solutions in which free AMPICILLIN and CURCUMIN were mixed.Conclusion: It seems that using nanotechnology could cause decrease the dosage of antibiotics and risk of having antibiotic resistance bacteria strains.

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APA: Copy

ALIHOSSEINI, FAEZEH, AZARMI, SHIRZAD, GHAFFARI, SOLMAZ, HAGHIGHAT, SETAREH, & REZAYAT SORKHABADI, SEYED MAHDI. (2016). SYNERGIC ANTIBACTERIAL EFFECT OF CURCUMIN WITH AMPICILLIN; FREE DRUG SOLUTIONS IN COMPARISON WITH SLN DISPERSIONS. ADVANCED PHARMACEUTICAL BULLETIN, 6(3), 461-465. SID. https://sid.ir/paper/331825/en

Vancouver: Copy

ALIHOSSEINI FAEZEH, AZARMI SHIRZAD, GHAFFARI SOLMAZ, HAGHIGHAT SETAREH, REZAYAT SORKHABADI SEYED MAHDI. SYNERGIC ANTIBACTERIAL EFFECT OF CURCUMIN WITH AMPICILLIN; FREE DRUG SOLUTIONS IN COMPARISON WITH SLN DISPERSIONS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2016;6(3):461-465. Available from: https://sid.ir/paper/331825/en

IEEE: Copy

FAEZEH ALIHOSSEINI, SHIRZAD AZARMI, SOLMAZ GHAFFARI, SETAREH HAGHIGHAT, and SEYED MAHDI REZAYAT SORKHABADI, “SYNERGIC ANTIBACTERIAL EFFECT OF CURCUMIN WITH AMPICILLIN; FREE DRUG SOLUTIONS IN COMPARISON WITH SLN DISPERSIONS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 6, no. 3, pp. 461–465, 2016, [Online]. Available: https://sid.ir/paper/331825/en

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