EXPRESSION OF MELANOCORTIN-4 RECEPTOR MRNA IN MALE RAT HYPOTHALAMUS DURING CHRONIC STRESS

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KARAMI KHEIRABAD MARYAM; NAMAVAR JAHROMI BAHIA; TAMADON AMIN; RAMEZANI AMIN; AHMADLOO SOMAYEH; SABET SARVESTANI FATEMEH; KOOHI HOSSEINABADI OMID

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Journal: International Journal of Molecular and Cellular Medicine Year:2015 | Volume:4 | Issue:3 Page(s): 182-187

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Title

EXPRESSION OF MELANOCORTIN-4 RECEPTOR MRNA IN MALE RAT HYPOTHALAMUS DURING CHRONIC STRESS

Author(s)

Keywords

CHRONIC STRESS

MELANOCORTIN 4 RECEPTOR (MC4R)

HYPOTHALAMUS

RATS

Abstract

The effects of CHRONIC STRESS and glucocorticoids receptor antagonist (RU486) on expression of melanocortin 4 receptor (MC4R) mRNA in arcuate nucleus (ARC) of male RATS were evaluated. In this study, adult male Sprague Dawley RATS were placed into four groups (n=6/group); stress, RU486, stress/RU486, and control groups. In stress group, the RATS were restrained, 1 h/day, for 12 days. In RU486 group, the RATS were injected RU486 for 12 days. In stress/RU486 group, the RATS were injected RU486 1 h before the stress process for 12 days. Relative expression of MC4R mRNA was determined using real-time PCR. Relative expression of MC4R mRNA in the stress group was higher than that of the control RATS (P<0.05). Relative expressions of MC4R mRNA were not different between the stress, RU486 and stress/RU486 groups (P>0.05). Chronic restraint stress causes increase in mRNA expression of MC4R in ARC and blockade of glucocorticoid receptors has no effect on this up-regulation.

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APA: Copy

KARAMI KHEIRABAD, MARYAM, NAMAVAR JAHROMI, BAHIA, TAMADON, AMIN, RAMEZANI, AMIN, AHMADLOO, SOMAYEH, SABET SARVESTANI, FATEMEH, & KOOHI HOSSEINABADI, OMID. (2015). EXPRESSION OF MELANOCORTIN-4 RECEPTOR MRNA IN MALE RAT HYPOTHALAMUS DURING CHRONIC STRESS. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, 4(3), 182-187. SID. https://sid.ir/paper/332129/en

Vancouver: Copy

KARAMI KHEIRABAD MARYAM, NAMAVAR JAHROMI BAHIA, TAMADON AMIN, RAMEZANI AMIN, AHMADLOO SOMAYEH, SABET SARVESTANI FATEMEH, KOOHI HOSSEINABADI OMID. EXPRESSION OF MELANOCORTIN-4 RECEPTOR MRNA IN MALE RAT HYPOTHALAMUS DURING CHRONIC STRESS. INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE[Internet]. 2015;4(3):182-187. Available from: https://sid.ir/paper/332129/en

IEEE: Copy

MARYAM KARAMI KHEIRABAD, BAHIA NAMAVAR JAHROMI, AMIN TAMADON, AMIN RAMEZANI, SOMAYEH AHMADLOO, FATEMEH SABET SARVESTANI, and OMID KOOHI HOSSEINABADI, “EXPRESSION OF MELANOCORTIN-4 RECEPTOR MRNA IN MALE RAT HYPOTHALAMUS DURING CHRONIC STRESS,” INTERNATIONAL JOURNAL OF MOLECULAR AND CELLULAR MEDICINE, vol. 4, no. 3, pp. 182–187, 2015, [Online]. Available: https://sid.ir/paper/332129/en

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