POLYCYSTIC OVARY MORPHOLOGY (PCOM) IN ESTRADIOL VALERATE TREATED MOUSE MODEL

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AMINI LEILA; TEHRANIAN NAJMEH; MOVAHEDIN MANSOUREH; RAMEZANI TEHRANI FAHIMEH; SOLTANGHORAEE HALEH

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Journal Paper

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Journal: International Journal of Women's Health and Reproduction Sciences Year:2016 | Volume:4 | Issue:1 Page(s): 13-17

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Title

POLYCYSTIC OVARY MORPHOLOGY (PCOM) IN ESTRADIOL VALERATE TREATED MOUSE MODEL

Author(s)

Keywords

ANIMAL MODELS

ESTRADIOL VALERATE

OVARIAN FOLLICLE

POLYCYSTIC OVARY SYNDROME

Abstract

Objectives: POLYCYSTIC OVARY SYNDROME (PCOS) is the most common endocrine disorder in women of reproductive age. Polycystic ovary (PCO) is a criterion for PCOS. Several ANIMAL MODELS of polycystic ovary morphology (PCOM) are developed in order to study PCOS aspects. The present study aimed to develop a polycystic ovarian model in mice.Materials and Methods: Thirty-four young adult female mice were divided equally into ESTRADIOL VALERATE (EV) treated and control groups. Mice in experimental group (n=18) received a single dose injection of EV (IM, 4 mg/kg). Weight and fertility rate of all mice were recorded. Morphology of OVARIAN FOLLICLEs was assessed too. Chi-square and independent t test were used for comparison between groups. P value less than 0.05 was considered as significant level.Results: After 60 days, the weight of EV-treated mice was significantly lower than control (P<0.04) and the experimental group did not show any significant changes in their body weight. Fertility rate in experimental group was significantly lower (P<0.001) than the other group. Follicle count showed that the number of preovulatory follicles and corpora lutea were lower (P<0.001) and atretic follicles were higher (P<0.001) significantly in EV-treated group in comparison to control. However, there were no significant differences in the number of primary, preantral and antral follicles between two groups.Conclusion: The polycystic ovary morphology can be induced in adult mice with a single dose of EV. This model may help to improve our knowledge on all aspects of PCOS.

Cites

The protective effect of vitamin E on rats’ ovarian follicles following an administration of diazinon: An experimental study

References

ESTRADIOL VALERATE-INDUCED POLYCYSTIC OVARY SYNDROME: AN ANIMAL MODEL STUDY

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APA: Copy

AMINI, LEILA, TEHRANIAN, NAJMEH, MOVAHEDIN, MANSOUREH, RAMEZANI TEHRANI, FAHIMEH, & SOLTANGHORAEE, HALEH. (2016). POLYCYSTIC OVARY MORPHOLOGY (PCOM) IN ESTRADIOL VALERATE TREATED MOUSE MODEL. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, 4(1), 13-17. SID. https://sid.ir/paper/334460/en

Vancouver: Copy

AMINI LEILA, TEHRANIAN NAJMEH, MOVAHEDIN MANSOUREH, RAMEZANI TEHRANI FAHIMEH, SOLTANGHORAEE HALEH. POLYCYSTIC OVARY MORPHOLOGY (PCOM) IN ESTRADIOL VALERATE TREATED MOUSE MODEL. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES[Internet]. 2016;4(1):13-17. Available from: https://sid.ir/paper/334460/en

IEEE: Copy

LEILA AMINI, NAJMEH TEHRANIAN, MANSOUREH MOVAHEDIN, FAHIMEH RAMEZANI TEHRANI, and HALEH SOLTANGHORAEE, “POLYCYSTIC OVARY MORPHOLOGY (PCOM) IN ESTRADIOL VALERATE TREATED MOUSE MODEL,” INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, vol. 4, no. 1, pp. 13–17, 2016, [Online]. Available: https://sid.ir/paper/334460/en

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