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Information Journal Paper

Title

Pre-Treatment with Metformin in Comparison with Post-Treatment Reduces Cerebral Ischemia Reperfusion Induced Injuries in Rats

Pages

  115-121

Abstract

 Objective: To explore the effects of pre versus post ischemic treatment with Metformin after Global cerebral ischemia in rats. Methods: Male Wister rats underwent forebrain ischemia by bilateral common carotid artery occlusion for 17 min. Metformin (200 mg/kg) or vehicle was given orally by gavage for 7-14 days. Rats were divided into: control, Metformin pre-treatment, Metformin post-treatment and Metformin pre and post continuous treatment groups. Cerebral infarct size, histopathology, myeloperoxidase and serum malondialdehyde were measured 7 days after ischemia. Results: Histopathological analysis showed that Metformin pre-treatment significantly decreased leukocyte infiltration, myeloperoxidase activity and also malondialdehyde level. Metformin pre-treatment and Metformin post-treatment reduced infarct size compared with the control group, but it was not significant in the pre and post continuous treatment group. Conclusion: Our findings suggest that pre-treatment with Metformin in comparison with post-treatment in experimental stroke can reduce the extent of brain damage and is more neuroprotective at least in part by inhibiting Oxidative stress and Inflammation.

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    APA: Copy

    KARIMIPOUR, MOJTABA, SHOJAEI ZARGHANI, SARA, Mohajer Milani, Majid, & SORAYA, HAMID. (2018). Pre-Treatment with Metformin in Comparison with Post-Treatment Reduces Cerebral Ischemia Reperfusion Induced Injuries in Rats. BULLETIN OF EMERGENCY AND TRAUMA BEAT, 6(2), 115-121. SID. https://sid.ir/paper/335095/en

    Vancouver: Copy

    KARIMIPOUR MOJTABA, SHOJAEI ZARGHANI SARA, Mohajer Milani Majid, SORAYA HAMID. Pre-Treatment with Metformin in Comparison with Post-Treatment Reduces Cerebral Ischemia Reperfusion Induced Injuries in Rats. BULLETIN OF EMERGENCY AND TRAUMA BEAT[Internet]. 2018;6(2):115-121. Available from: https://sid.ir/paper/335095/en

    IEEE: Copy

    MOJTABA KARIMIPOUR, SARA SHOJAEI ZARGHANI, Majid Mohajer Milani, and HAMID SORAYA, “Pre-Treatment with Metformin in Comparison with Post-Treatment Reduces Cerebral Ischemia Reperfusion Induced Injuries in Rats,” BULLETIN OF EMERGENCY AND TRAUMA BEAT, vol. 6, no. 2, pp. 115–121, 2018, [Online]. Available: https://sid.ir/paper/335095/en

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