THE MUTATIONS OF RET PROTO-ONCOGENE IN MEDULLARY THYROID CARCINOMAS IN IRAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AZIZI FEREYDOUN; NABIPOUR I.; GHASEMI FERESHTEH; KIABI SH.; BARADAR JALILI R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian South Medical Journal Year:2002 | Volume:4 | Issue:2 Page(s): 79-87

Download Full-Text

Persian Verion

View:

1,576

Download:

Cites:

Information Journal Paper

Title

THE MUTATIONS OF RET PROTO-ONCOGENE IN MEDULLARY THYROID CARCINOMAS IN IRAN

Author(s)

Keywords

MEDULLARY THYROID CANCERQ4

PROTO-ONCOGENEQ4

RETQ4

MUTATIONQ3

Abstract

Medullary thyroid carcinoma (MTC) occurs both sporadically and in the autosomal dominantly inherited multiple endocrine neoplasia (MEN) type 2 syndromes. The distinction between true sporadic MTC and a new MUTATION familial case is important for future clinical management of both the patient and family. The susceptibility gene for hereditary MTC is the RET PROTO-ONCOGENE. DNA analysis for germline MUTATIONs of the RET PROTO-ONCOGENE was performed in a series of 24 patients with MTC [apparently sporadic MTC (20 cases), familial MTC (2 cases), MEN 2A (one case) and MEN 2B (one case)] to determine whether they were true sporadic cases or hereditary forms. Genomic DNA was amplified using polymerase chain reaction (PCR) and oligonucleotide primers for exons 10 & 11. The PCR products were examined by restriction enzymes analysis to detect the MUTATIONs. One of the 20 patients with apparent sporadic MTC had exon 10 MUTATION (Cys620 Arg); and exon 11 MUTATION (Cys-634 Trp) was also found in index case with MEN 2A. No MUTATION was detected in the other patients. Three of six evaluated members of the MEN 2A patients had the same MUTATION. We conclude routine application of RET PROTO-ONCOGENE testing should be included in all cases of apparent sporadic MTC.

Cites

References

No record.

Cite

APA: Copy

AZIZI, FEREYDOUN, NABIPOUR, I., GHASEMI, FERESHTEH, KIABI, SH., & BARADAR JALILI, R.. (2002). THE MUTATIONS OF RET PROTO-ONCOGENE IN MEDULLARY THYROID CARCINOMAS IN IRAN. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 4(2), 79-87. SID. https://sid.ir/paper/33516/en

Vancouver: Copy

AZIZI FEREYDOUN, NABIPOUR I., GHASEMI FERESHTEH, KIABI SH., BARADAR JALILI R.. THE MUTATIONS OF RET PROTO-ONCOGENE IN MEDULLARY THYROID CARCINOMAS IN IRAN. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2002;4(2):79-87. Available from: https://sid.ir/paper/33516/en

IEEE: Copy

FEREYDOUN AZIZI, I. NABIPOUR, FERESHTEH GHASEMI, SH. KIABI, and R. BARADAR JALILI, “THE MUTATIONS OF RET PROTO-ONCOGENE IN MEDULLARY THYROID CARCINOMAS IN IRAN,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 4, no. 2, pp. 79–87, 2002, [Online]. Available: https://sid.ir/paper/33516/en

Related Journal Papers