STUDY OF POLYMORPHISM PRO198LEU OF GPX-1 GENE AS A RISK FACTOR IN PATIENTS WITH COLORECTAL CANCER

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SALEHI Z.; HOSSEINI F.; AJAMIAN F.; SAEIDI SAEDI H.

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Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2016 | Volume:19 | Issue:3 Page(s): 334-341

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Title

STUDY OF POLYMORPHISM PRO198LEU OF GPX-1 GENE AS A RISK FACTOR IN PATIENTS WITH COLORECTAL CANCER

Author(s)

SALEHI Z. | HOSSEINI F. | AJAMIAN F. | SAEIDI SAEDI H. | Issue Writer Certificate

Keywords

COLORECTAL CANCERQ2

GPX-1Q1

ROSQ1

GENE POLYMORPHISMQ1

Abstract

Background: Oxidative stress is a condition in which the balance is disrupted between reactive oxygen species (ROS) and antioxidant. Glutathione peroxidase 1 (GPX-1), as one of the antioxidant enzyme remove the ROS in a continuous process. One of the functional polymorphism of GPX1 gene is Pro198Leu polymorphism. The aim of this study was to study the association between GPX-1 Pro198Leu polymorphism with the risk of COLORECTAL CANCER.Materials & Methods: in this case-control study, 130 patients with COLORECTAL CANCER were compared with 170 healthy subjects. Genomic DNA was extracted from peripheral blood leukocytes. Determination of DNA genotyping in GPX-1 Pro198Leu polymorphism were performed by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The c2-test was used for statistical analyses.Results: The GPX1 genotype frequencies were 64% for CC, 24% for CT and 12% for TT in control group, and 60% for CC, 30% for CT and 12% for TT among the patients. The C allele frequency in cases and controls including 0.75 and 0.76 and T allele frequency was including 0.25 and 0.24. Based on these data, there was no significant differences in the GPX1 Pro198Leu genotypes and allele frequencies between cases and controls (P=0.2).Conclusion: The result of this study suggested that GPX-1 Pro198Leu polymorphism could not be a risk factor for COLORECTAL CANCER. However, studies in larger populations are needed in order to confirm the results.

Cites

BASIC PRINCIPLES OF REPORTING RESULTS OF CONVENTIONAL STATISTICAL TESTS IN SCIENTIFIC BIOMEDICAL ARTICLES

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APA: Copy

SALEHI, Z., HOSSEINI, F., AJAMIAN, F., & SAEIDI SAEDI, H.. (2016). STUDY OF POLYMORPHISM PRO198LEU OF GPX-1 GENE AS A RISK FACTOR IN PATIENTS WITH COLORECTAL CANCER. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 19(3 ), 334-341. SID. https://sid.ir/paper/33686/en

Vancouver: Copy

SALEHI Z., HOSSEINI F., AJAMIAN F., SAEIDI SAEDI H.. STUDY OF POLYMORPHISM PRO198LEU OF GPX-1 GENE AS A RISK FACTOR IN PATIENTS WITH COLORECTAL CANCER. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2016;19(3 ):334-341. Available from: https://sid.ir/paper/33686/en

IEEE: Copy

Z. SALEHI, F. HOSSEINI, F. AJAMIAN, and H. SAEIDI SAEDI, “STUDY OF POLYMORPHISM PRO198LEU OF GPX-1 GENE AS A RISK FACTOR IN PATIENTS WITH COLORECTAL CANCER,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 19, no. 3 , pp. 334–341, 2016, [Online]. Available: https://sid.ir/paper/33686/en

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