THE EFFECT OF ANTIANGIOGENESIS PROTEINS, ISOLATED FROM SHARK CARTILAGE, ON CHICK CHORIOALLANTOIC MEMBRANE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BARGAHI A.; RABANI CHADEGANI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2007 | Volume:10 | Issue:1 Page(s): 1-8

Download Full-Text

Persian Verion

View:

790

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF ANTIANGIOGENESIS PROTEINS, ISOLATED FROM SHARK CARTILAGE, ON CHICK CHORIOALLANTOIC MEMBRANE

Author(s)

BARGAHI A. | RABANI CHADEGANI A. | Issue Writer Certificate

Keywords

ANGIOGENESISQ2

CARTILAGEQ2

SHARKQ3

CANCERQ3

Abstract

Background: SHARK CARTILAGE has been considered as a natural anti-ANGIOGENESIS material in traditional medicine since long ago, and a broad range of biological functions such as inhibition of endothelial cell adhesion, proliferation, migration and digestion of the extracellular matrix has been reported for it. Because of its widespread therapeutic usage in controlling ANGIOGENESIS, we have investigated the antiANGIOGENESIS activity of the SHARK CARTILAGE proteins, in the present study. Methods: CARTILAGE proteins were extracted in 100 mM sodium acetate buffer (pH=4.8) containing 4M guanidinium hydrochloride in the presence of protease inhibitors. The extract was then chromatographed on cation and anion exchange columns and the fractions were characterized for ANGIOGENESIS properties (like number and thickness of blood vessels, number and severity of bends in accessory vessels and abnormal colour of membrane) using chick chorioallantoic membrane (CAM) assay and gel electrophoresis techniques. Results: The results showed high antiANGIOGENESIS activity of protein fraction A1 extracted from SHARK CARTILAGE comparing to the controls and other trial groups. Survey on the active protein fraction A1 on gel electrophoresis showed existence of low molecular weight proteins between 14-16 kDa. Conclusion: SHARK CARTILAGE has an antiANGIOGENESIS effect. Therefore, considering the importance and increasing needs of novel drugs for ANGIOGENESIS-based diseases, further molecular surveys on these ANGIOGENESIS proteins are recommended.

Cites

THE SEA, THE FUTURE PHARMACY

References

No record.

Cite

APA: Copy

BARGAHI, A., & RABANI CHADEGANI, A.. (2007). THE EFFECT OF ANTIANGIOGENESIS PROTEINS, ISOLATED FROM SHARK CARTILAGE, ON CHICK CHORIOALLANTOIC MEMBRANE. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 10(1), 1-8. SID. https://sid.ir/paper/33701/en

Vancouver: Copy

BARGAHI A., RABANI CHADEGANI A.. THE EFFECT OF ANTIANGIOGENESIS PROTEINS, ISOLATED FROM SHARK CARTILAGE, ON CHICK CHORIOALLANTOIC MEMBRANE. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2007;10(1):1-8. Available from: https://sid.ir/paper/33701/en

IEEE: Copy

A. BARGAHI, and A. RABANI CHADEGANI, “THE EFFECT OF ANTIANGIOGENESIS PROTEINS, ISOLATED FROM SHARK CARTILAGE, ON CHICK CHORIOALLANTOIC MEMBRANE,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 10, no. 1, pp. 1–8, 2007, [Online]. Available: https://sid.ir/paper/33701/en

Related Journal Papers