Effect of Average Annual Mean Serum Ferritin Levels on QTc Interval and QTc Dispersion in Beta-Thalassemia Major

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GHANDI YAZDAN; SHARIFI MEHRZAD; EGHBALI AZIZ; HABIBI DANIAL

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Journal Paper

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Journal: Journal of Pediatric Perspectives Year:2017 | Volume:5 | Issue:8 (44) Page(s): 5431-5440

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Title

Effect of Average Annual Mean Serum Ferritin Levels on QTc Interval and QTc Dispersion in Beta-Thalassemia Major

Author(s)

GHANDI YAZDAN | SHARIFI MEHRZAD | EGHBALI AZIZ | HABIBI DANIAL | Issue Writer Certificate

Keywords

Arrhythmia

Beta-thalassemia major

Ferritin

Abstract

Background There is evidence indicating impaired cardiomyocytic contractility, delayed electrical conduction and increased electrophysiological heterogeneities due to iron toxicity in Beta-thalassemia major patients. In the present study, we compared the electrocardiographic and echocardiographic features of betathalassemia major patients with a healthy control group. Materials and Methods The average annual serum Ferritin levels of fifty Beta-thalassemia major patients were assessed. For each patient, corrected QT (QTc) intervals and QTc dispersions (QTcd) were calculated and V1S and V5R were measured. All subjects underwent two-dimensional M-mode echocardiography and Doppler study and were compared with 50 healthy subjects as a control group. Results QTc interval and dispersion were significantly higher in Beta-thalassemia major patients (P= 0. 001). The mean V5R (20. 04 ± 4. 34 vs. 17. 14 ± 2. 55 mm) and V1S (10. 24 ± 2. 62 vs. 7. 83 ± 0. 38 mm) showed considerably higher mean values in patients in comparison with control group. Peak mitral inflow velocity at early diastole and early to late ratio in the case-group was markedly higher (P<0. 001), whereas, early deceleration time (P=0. 01) and Isovolumic relaxation time (IVRT) (P=0. 001), were meaningfully lower than the control group. There was positive correlation between age and QTc (r= 0. 831, P=0. 001) and QTc dispersion (r= 0. 710, P=0. 001) and negative correlation between serum level of Ferritin and V5R (r=-0. 271, P= 0. 05). Conclusion Measurement of the QTc interval and dispersion can be used for early detection of cardiac involvement, especially in asymptomatic beta-thalassemia patients with Ferritin levels higher than 2, 500 ng/dl.

Cites

The Effect of Iron Replacement Therapy on Electrocardiographic Consequences in Pediatric Patients

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APA: Copy

GHANDI, YAZDAN, SHARIFI, MEHRZAD, EGHBALI, AZIZ, & HABIBI, DANIAL. (2017). Effect of Average Annual Mean Serum Ferritin Levels on QTc Interval and QTc Dispersion in Beta-Thalassemia Major. INTERNATIONAL JOURNAL OF PEDIATRICS, 5(8 (44)), 5431-5440. SID. https://sid.ir/paper/337830/en

Vancouver: Copy

GHANDI YAZDAN, SHARIFI MEHRZAD, EGHBALI AZIZ, HABIBI DANIAL. Effect of Average Annual Mean Serum Ferritin Levels on QTc Interval and QTc Dispersion in Beta-Thalassemia Major. INTERNATIONAL JOURNAL OF PEDIATRICS[Internet]. 2017;5(8 (44)):5431-5440. Available from: https://sid.ir/paper/337830/en

IEEE: Copy

YAZDAN GHANDI, MEHRZAD SHARIFI, AZIZ EGHBALI, and DANIAL HABIBI, “Effect of Average Annual Mean Serum Ferritin Levels on QTc Interval and QTc Dispersion in Beta-Thalassemia Major,” INTERNATIONAL JOURNAL OF PEDIATRICS, vol. 5, no. 8 (44), pp. 5431–5440, 2017, [Online]. Available: https://sid.ir/paper/337830/en

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