EFFECT OF ESTRADIOL VALERATE ON PANCREATIC BETA CELLS RESISTANCE IN DIABETIC FEMALE RATS BY STREPTOZOTOCIN

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AZIZI Z.; MANSOORPOOR S.; SABZEHVARIFARD A.; ASAIE S.; RANJBAR OMRANI GH.

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Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2014 | Volume:17 | Issue:2 Page(s): 107-119

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Title

EFFECT OF ESTRADIOL VALERATE ON PANCREATIC BETA CELLS RESISTANCE IN DIABETIC FEMALE RATS BY STREPTOZOTOCIN

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Keywords

ESTRADIOLQ2

PANCREASQ2

STREPTOZOTOCINQ3

STEREOLOGYQ2

Abstract

Background: Diabetes mellitus (DM) is the most common metabolic disorder, with defective insulin secretion or insulin receptor function, or both. We examined the protective effect of ESTRADIOL against the destruction of pancreatic b-cells by STREPTOZOTOCIN (STZ).Material and Methods: This empirical research involved 56 adult female rats (180-200 g) randomized to: group 1, food and water; group 2, olive oil injection; group 3, STZ-induced DM; group 4, castrated rats; group 5, gonadectomy+STZ; group 6, gonadal hormone+STZ; group 7, gonadal hormone+STZ+gonadal hormone. ESTRADIOL valerate was injected intramuscularly (5 mg/kg in group 6, 4 weeks before DM induction, and 5 mg/kg in group 7, 4 weeks before and 2 weeks after DM). Diabetes was induced by 60 mg/kg, intraperitoneal STZ (STZ; 20130 Sigma-Aldrich) in citrate buffer. Data were analyzed using SPSS 16 software.Results: In groups 6 and 7 (ESTRADIOL) blood glucose was higher than in groups 3and 5 and in group 7 was significantly higher (P£0.05). Groups 6 and 7 also had higher serum insulin concentrations (P£0.05) and absolute numbers of islet cells (P£0.05) compared to groups 3 and 5.Conclusion: ESTRADIOL exerted a protective effect against early STZ-induced apoptotic damage to pancreatic b-cells.

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APA: Copy

AZIZI, Z., MANSOORPOOR, S., SABZEHVARIFARD, A., ASAIE, S., & RANJBAR OMRANI, GH.. (2014). EFFECT OF ESTRADIOL VALERATE ON PANCREATIC BETA CELLS RESISTANCE IN DIABETIC FEMALE RATS BY STREPTOZOTOCIN. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 17(2), 107-119. SID. https://sid.ir/paper/34005/en

Vancouver: Copy

AZIZI Z., MANSOORPOOR S., SABZEHVARIFARD A., ASAIE S., RANJBAR OMRANI GH.. EFFECT OF ESTRADIOL VALERATE ON PANCREATIC BETA CELLS RESISTANCE IN DIABETIC FEMALE RATS BY STREPTOZOTOCIN. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2014;17(2):107-119. Available from: https://sid.ir/paper/34005/en

IEEE: Copy

Z. AZIZI, S. MANSOORPOOR, A. SABZEHVARIFARD, S. ASAIE, and GH. RANJBAR OMRANI, “EFFECT OF ESTRADIOL VALERATE ON PANCREATIC BETA CELLS RESISTANCE IN DIABETIC FEMALE RATS BY STREPTOZOTOCIN,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 17, no. 2, pp. 107–119, 2014, [Online]. Available: https://sid.ir/paper/34005/en

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