NANO PACKAGED DIBLOCK AND CURCUMIN: A NEW APPROACH INORDER TO DRUG RESISTANCE IN BREAST CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAJI GHOLAMI S.; VAISE MALEKSHAHI Z.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2017 | Volume:19 | Issue:6 Page(s): 951-961

Download Full-Text

Persian Verion

View:

700

Download:

Cites:

Information Journal Paper

Title

NANO PACKAGED DIBLOCK AND CURCUMIN: A NEW APPROACH INORDER TO DRUG RESISTANCE IN BREAST CANCER

Author(s)

HAJI GHOLAMI S. | VAISE MALEKSHAHI Z. | Issue Writer Certificate

Keywords

CURCUMINQ1

TAMOXIFENQ2

POLYMER NANOQ1

CARRIERQ1

BREAST CANCERQ1

Abstract

Background: BREAST CANCER is one of the causes of mortality in the world. Half of patients with metastatic extend resistance to TAMOXIFEN and almost all patients eventually become resistant to TAMOXIFEN. Inorder to counteract with the negative effects of TAMOXIFEN, this drug have been placed in combination with the CURCUMIN. Anti- cancer substance which is less toxic than TAMOXIFEN. In this study, Diblock (Dendrosome) Nano polymer was used in order to TAMOXIFEN packaging along with CURCUMIN. Anti-cancer efficacy of the obtained compound (Diblock, TAMOXIFEN and CURCUMIN) was evaluated in TAMOXIFEN-resistant (TR) MCF-7 cells and Fibroblast cells.Material and Methods: MTT Assay was used to evaluate anti-proliferation effect and drug toxicity.Flow cytometry and Annexin-V-FLUOS were used inorder to assay anti-proliferation effect and induction of apoptosis, respectively.Results: Nano-compound has less toxicity effects on normal cells compared with TAMOXIFEN and increased apoptosis activity and decreased proliferation in MCF-7 cells which are resistant to TAMOXIFEN. CURCUMIN and TAMOXIFEN have more apoptotic potential than TAMOXIFEN alone, Nano-Tamoxifen or Nano- CURCUMIN.Conclusion: Results of this study showed that changes in TAMOXIFEN by CURCUMIN polymeric nanocarrier help to more effective treatment of BREAST CANCER.

Cites

No record.

References

CURCUMIN–PIPERINE/CURCUMIN QUERCETIN/CURCUMIN–SILIBININ DUAL DRUG-LOADED NANOPARTICULATE COMBINATION THERAPY: A NOVEL APPROACH TO TARGET AND TREAT MULTIDRUG-RESISTANT CANCERS

Cite

APA: Copy

HAJI GHOLAMI, S., & VAISE MALEKSHAHI, Z.. (2017). NANO PACKAGED DIBLOCK AND CURCUMIN: A NEW APPROACH INORDER TO DRUG RESISTANCE IN BREAST CANCER. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 19(6), 951-961. SID. https://sid.ir/paper/34012/en

Vancouver: Copy

HAJI GHOLAMI S., VAISE MALEKSHAHI Z.. NANO PACKAGED DIBLOCK AND CURCUMIN: A NEW APPROACH INORDER TO DRUG RESISTANCE IN BREAST CANCER. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2017;19(6):951-961. Available from: https://sid.ir/paper/34012/en

IEEE: Copy

S. HAJI GHOLAMI, and Z. VAISE MALEKSHAHI, “NANO PACKAGED DIBLOCK AND CURCUMIN: A NEW APPROACH INORDER TO DRUG RESISTANCE IN BREAST CANCER,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 19, no. 6, pp. 951–961, 2017, [Online]. Available: https://sid.ir/paper/34012/en

Related Journal Papers