CHROMOSOMAL REARRANGEMENT AND BIOINFORMATIC STUDIES OF THE INVOLVED GENES IN DMBA-INDUCED BREAST CANCER IN SD RAT STRAINS AND VERIFICATION OF THEIR SYNTENIC SEGMENTS IN HUMAN CHROMOSOMS

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HAMTA A.; SHARIATZADEH S.M.A.; SOLEYMANI MALEK; SEYFI FATEMEH

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Paper Information

Journal: Journal of Kerman University of Medical Sciences Year:2010 | Volume:17 | Issue:3 Page(s): 191-207

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Title

CHROMOSOMAL REARRANGEMENT AND BIOINFORMATIC STUDIES OF THE INVOLVED GENES IN DMBA-INDUCED BREAST CANCER IN SD RAT STRAINS AND VERIFICATION OF THEIR SYNTENIC SEGMENTS IN HUMAN CHROMOSOMS

Author(s)

HAMTA A. | SHARIATZADEH S.M.A. | SOLEYMANI MALEK | SEYFI FATEMEH | Issue Writer Certificate

Keywords

BREAST NEOPLASMSQ2

CHROMOSOME ABERRATIONSQ2

CHROMOSOME–BANDINGQ3

DMBAQ2

RATSQ2

INBRED STRAINSQ2

Abstract

Background & Aims: Breast cancer is the most common malignant neoplasm in women and has an increasing rate in both developed and developing countries. According to Iranian National Cancer Registration report, breast cancer has the first rank in women. Breast cancer is the major cause of mortality in women under 55 years old. The present study was performed to find the most probable involved genes in breast cancer.Methods: In this work, we have gavaged 10 mg DMBA solved in 0.5 ml sesame oil to the DMBA-treated SD rat strains. Before proceeding to cell culture, samples were verified in pathological and immunohistochemistry approaches, and then we performed metaphase chromosomal preparations and finally performed G-banding staining. The most common chromosomal changes were recorded and genes in affected area were determined and a genes-list by comparing genome of rat and human in chromosomal changed segments were prepared.Results: Our data showed a wide range of numerical and structural changes in different chromosomes. We found recurrently gain in chromosomes no. 1, 3, 9 and loss in chromosomes no. 8 and 15 and also deletion in chromosomes no. 2, 5, 8, 16, 19 and addition in chromosome no. 2, 12 and 19.Conclusion: According to these chromosomal changes and based on bio-informatics studies we predicted that the DAB2, KLF4, HSPA8, CDKN2A, CALB2, HPR, CHFR, ALDH2, AQP3, ABCA1, ALDOB, ASH2L, LSM1, FGFR1, HSPA8, ZFHX3 and SFRP1 are probably involved in the development of breast cancer.

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APA: Copy

HAMTA, A., SHARIATZADEH, S.M.A., SOLEYMANI, MALEK, & SEYFI, FATEMEH. (2010). CHROMOSOMAL REARRANGEMENT AND BIOINFORMATIC STUDIES OF THE INVOLVED GENES IN DMBA-INDUCED BREAST CANCER IN SD RAT STRAINS AND VERIFICATION OF THEIR SYNTENIC SEGMENTS IN HUMAN CHROMOSOMS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 17(3), 191-207. SID. https://sid.ir/paper/342/en

Vancouver: Copy

HAMTA A., SHARIATZADEH S.M.A., SOLEYMANI MALEK, SEYFI FATEMEH. CHROMOSOMAL REARRANGEMENT AND BIOINFORMATIC STUDIES OF THE INVOLVED GENES IN DMBA-INDUCED BREAST CANCER IN SD RAT STRAINS AND VERIFICATION OF THEIR SYNTENIC SEGMENTS IN HUMAN CHROMOSOMS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;17(3):191-207. Available from: https://sid.ir/paper/342/en

IEEE: Copy

A. HAMTA, S.M.A. SHARIATZADEH, MALEK SOLEYMANI, and FATEMEH SEYFI, “CHROMOSOMAL REARRANGEMENT AND BIOINFORMATIC STUDIES OF THE INVOLVED GENES IN DMBA-INDUCED BREAST CANCER IN SD RAT STRAINS AND VERIFICATION OF THEIR SYNTENIC SEGMENTS IN HUMAN CHROMOSOMS,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 3, pp. 191–207, 2010, [Online]. Available: https://sid.ir/paper/342/en

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