EXPERIMENTAL PRODUCTION AND INITIAL IMAGING OF [18F]-14-FLUORO-6- THIA-HEPTADECANOIC ACID ([18F]-FTHA) FOR MYOCARDIAL PERFORMANCE

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JALILIAN A.R.; AKHLAGHI M.; SADADI F.; MIRZAEI MOHAMMAD; KARIMIAN A.R.; POULADI M.; YARI KAMRANI Y.; MORADKHANI S.; SHADANPOUR N.

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2006 | Volume:14 | Issue:26 Page(s): 35-41

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Title

EXPERIMENTAL PRODUCTION AND INITIAL IMAGING OF [18F]-14-FLUORO-6- THIA-HEPTADECANOIC ACID ([18F]-FTHA) FOR MYOCARDIAL PERFORMANCE

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Keywords

RADIOPHARMACEUTICALQ1

FLUORINE-18Q1

PETQ1

MYOCARDIUMQ1

Abstract

Introduction: [18F]-6-thia-14-fluoro-heptadecanoic acid 3b, a free fatty acid, has been used in myocardial PET imaging. In order to establish an automated synthesis module for routine production in the country, a study performed for optimization of the production conditions as well as making modifications.Methods: [18F] Benzyl-14-Fluoro-6-thia-heptadecanoate 2b was prepared in no-carrier-added (n.c.a) form from Benzyl-14-tosyloxy-6-thia-heptadecanoate 1 in one step at 90°C in Kryptofix2.2.2 [18F] and acetonitrile as the solvent followed by Silica column chromatography. The radiolabeled ester 2 was then hydrolyzed to yield [18F]-6-thia-14-fluoro-heptadecanoic 3b. The final solution was concentrated using C18 SPE system and administered to normal rats for biodistribution as well as co-incidence imaging studies.Results: The synthesis took 15 min with overall radiochemical yield of 15-25% (EOS) and chemical radiochemical purity more than 94%. Automation was performed using a two-pot synthesis. The best imaging time was shown to be 140-180 minutes post injection.Conclusions: Using this procedure a fast, reliable, automated synthesis for the cordial PET tracer, i.e. [18F]-FTHA can be obtained without HPLC purification step.

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APA: Copy

JALILIAN, A.R., AKHLAGHI, M., SADADI, F., MIRZAEI, MOHAMMAD, KARIMIAN, A.R., POULADI, M., YARI KAMRANI, Y., MORADKHANI, S., & SHADANPOUR, N.. (2006). EXPERIMENTAL PRODUCTION AND INITIAL IMAGING OF [¹⁸F]-14-FLUORO-6- THIA-HEPTADECANOIC ACID ([¹⁸F]-FTHA) FOR MYOCARDIAL PERFORMANCE. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 14(26), 35-41. SID. https://sid.ir/paper/34216/en

Vancouver: Copy

JALILIAN A.R., AKHLAGHI M., SADADI F., MIRZAEI MOHAMMAD, KARIMIAN A.R., POULADI M., YARI KAMRANI Y., MORADKHANI S., SHADANPOUR N.. EXPERIMENTAL PRODUCTION AND INITIAL IMAGING OF [¹⁸F]-14-FLUORO-6- THIA-HEPTADECANOIC ACID ([¹⁸F]-FTHA) FOR MYOCARDIAL PERFORMANCE. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2006;14(26):35-41. Available from: https://sid.ir/paper/34216/en

IEEE: Copy

A.R. JALILIAN, M. AKHLAGHI, F. SADADI, MOHAMMAD MIRZAEI, A.R. KARIMIAN, M. POULADI, Y. YARI KAMRANI, S. MORADKHANI, and N. SHADANPOUR, “EXPERIMENTAL PRODUCTION AND INITIAL IMAGING OF [¹⁸F]-14-FLUORO-6- THIA-HEPTADECANOIC ACID ([¹⁸F]-FTHA) FOR MYOCARDIAL PERFORMANCE,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 14, no. 26, pp. 35–41, 2006, [Online]. Available: https://sid.ir/paper/34216/en

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