PREPARATION OF AN ARTIFICIAL MATRIX TO REPLACE HUMAN STANDARDS OF PROSTATE SPECIFIC ANTIGEN IRMA ASSAY KIT

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FOROUTAN H.; NAJAFI R.; BABAEI M.

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Paper Information

Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2006 | Volume:14 | Issue:25 Page(s): 1-12

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Information Journal Paper

Title

PREPARATION OF AN ARTIFICIAL MATRIX TO REPLACE HUMAN STANDARDS OF PROSTATE SPECIFIC ANTIGEN IRMA ASSAY KIT

Author(s)

FOROUTAN H. | NAJAFI R. | BABAEI M. | Issue Writer Certificate

Keywords

PROSTATEQ2

PSAQ2

RIAQ2

STANDARD MATRIXQ2

HUMAN SERUMQ2

Abstract

Introduction: PROSTATE specific antigen (PSA) is one of the most sensitive markers for diagnosis of PROSTATE cancer. Immunoradiometric kit (IRMA) is a common and sensitive method for determination of PSA in clinical laboratories. This kit has four major components: solid phase coated with monoclonal antibody, pair antibody labeled with I-125, series of standards in different ranges of concentration and lyophilized control samples. In IRMA method, PSA is determined in HUMAN SERUM. Therefore, matrix of standards have to be similar to HUMAN SERUM. Using HUMAN SERUM as standard has many shortcomings namely biohazard contamination, instability, serum protein precipitation and unavailability. Artificial matrix however, is an ideal substitute for HUMAN SERUM.Methods: In this study, we used an artificial matrix as standard sample and evaluated its effects including reproducibility, sensitivity, precision and stability for determination of PSA in comparison to HUMAN SERUM.Results: The specificity, sensitivity, storage condition and the stability of these standards prepared with artificial matrix were studied. Similar results in comparison to HUMAN SERUM was observed.Conclusion: The prepared standards with this matrix had suitable and ideal properties and it can be used as standard in PSA assay kit.

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APA: Copy

FOROUTAN, H., NAJAFI, R., & BABAEI, M.. (2006). PREPARATION OF AN ARTIFICIAL MATRIX TO REPLACE HUMAN STANDARDS OF PROSTATE SPECIFIC ANTIGEN IRMA ASSAY KIT. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 14(25), 1-12. SID. https://sid.ir/paper/34232/en

Vancouver: Copy

FOROUTAN H., NAJAFI R., BABAEI M.. PREPARATION OF AN ARTIFICIAL MATRIX TO REPLACE HUMAN STANDARDS OF PROSTATE SPECIFIC ANTIGEN IRMA ASSAY KIT. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2006;14(25):1-12. Available from: https://sid.ir/paper/34232/en

IEEE: Copy

H. FOROUTAN, R. NAJAFI, and M. BABAEI, “PREPARATION OF AN ARTIFICIAL MATRIX TO REPLACE HUMAN STANDARDS OF PROSTATE SPECIFIC ANTIGEN IRMA ASSAY KIT,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 14, no. 25, pp. 1–12, 2006, [Online]. Available: https://sid.ir/paper/34232/en

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