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Title

DETERMINATION OF HAPTOGLOBIN GENOTYPE IN AN IRANIAN POPULATION WITH IDIOPATHIC GENERALIZED EPILEPSY

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Abstract

 Background: HAPTOGLOBIN (Hp) is a plasma a2-sialoglycoprotein that contains alpha and beta chains. It displays in three common phenotypes, Hp1-1, Hp2-1, and Hp2-2. Proteins expressed by polymorphic genes have grossly different molecular sizes resulting in different diffusion rates in the brain. HAPTOGLOBIN expressed by the Hp2-2 genotype has lower hemoglobin-binding capacity than Hp1-1 or Hp2-1 and is associated with idiopathic generalized EPILEPSY.Methods: To determine polymorphism in HAPTOGLOBIN genes in patients with idiopathic generalized tonic-clonic seizures, 42 men, 42 women, and 50 controls were selected for this study. Genomic DNA was extracted from blood and studied by polymerase chain reactions (PCR).Results: The amplified fragments for the Hp1-1 and Hp2-2 genotypes were 1757 and 3481 base pairs (bp) respectively, and the Hp2-1 genotype had both fragments, in addition to a 349-bp fragment. The distribution of the three majorHp phenotypes in EPILEPSY patients was 28.6 (1-1), 38.1 (2-1), and 33.3% (2-2) in the men, and 31 (1-1), 40.5 (2-1), and 28.6% (2-2) in the women. The distribution of Hp genotypes in controls was 22 (1-1), 40 (2-1), and 38% (2-2).Conclusion:We show that all Hp genotypes participate in idiopathic generalized EPILEPSY.

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    APA: Copy

    AL BALAGHEE, SUKAINA, AL BALAGHEE, ZEINAB, SHABANI, ASHRAF, GHADAM, PARINAZ, BANDEHPOUR, MOJGAN, ASKARI MEHR, ALI, & KAZEMI, BAHRAM. (2015). DETERMINATION OF HAPTOGLOBIN GENOTYPE IN AN IRANIAN POPULATION WITH IDIOPATHIC GENERALIZED EPILEPSY. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 3(2), 0-0. SID. https://sid.ir/paper/343104/en

    Vancouver: Copy

    AL BALAGHEE SUKAINA, AL BALAGHEE ZEINAB, SHABANI ASHRAF, GHADAM PARINAZ, BANDEHPOUR MOJGAN, ASKARI MEHR ALI, KAZEMI BAHRAM. DETERMINATION OF HAPTOGLOBIN GENOTYPE IN AN IRANIAN POPULATION WITH IDIOPATHIC GENERALIZED EPILEPSY. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[Internet]. 2015;3(2):0-0. Available from: https://sid.ir/paper/343104/en

    IEEE: Copy

    SUKAINA AL BALAGHEE, ZEINAB AL BALAGHEE, ASHRAF SHABANI, PARINAZ GHADAM, MOJGAN BANDEHPOUR, ALI ASKARI MEHR, and BAHRAM KAZEMI, “DETERMINATION OF HAPTOGLOBIN GENOTYPE IN AN IRANIAN POPULATION WITH IDIOPATHIC GENERALIZED EPILEPSY,” REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 3, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/343104/en

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