مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

295
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

176
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

CYTOTOXIC EFFECT OF COUSINIA VERBASCIFOLIA BUNGE AGAINST OVCAR-3 AND HT-29 CANCER CELLS

Pages

  15-19

Abstract

 Introduction: Little information is available about phytochemical and biological properties of Cousinia genus. In a primary study, seven Cousinia species including C. verbascifolia showed cytotoxic activity ranged between 18.4 ± 0.59 to 87.9 ± 0.58 mg/mL. To the best of our knowledge, no other biological studies have been conducted on this plant. Therefore, in this study the cytotoxic effect of COUSINIA VERBASCIFOLIA Bunge against OVCAR-3 and HT-29 cancer cells was evaluated.Methods: Filtration and in vacuo concentration of methanol extract resulted in a green gum which was subjected on reverse column chromatography. Semi polar fraction (41.3 g) eluted with water: methanol (20: 80), was then subjected on a silica gel column chromatography using hexane/acetone and resulted in 11 fractions. Finally, cytotoxic activities against ovarian and colon cancer cells were determined at a wavelength of 570 nm by Matrix metalloproteinase protein (MTT) standard method.Results: None of the fractions showed highly cytotoxic activity. Based on NCI, fractions Fr.1, Fr.2, Fr.4, Fr.5, Fr.6, Fr.8 and Fr.10 showed moderately CYTOTOXICITY with IC50 values ranged between 119 to 190 mg/mL against OVCAR-3 cells. Fractions Fr.1, Fr.2, Fr.6, Fr.7 and Fr.8 showed moderately cytotoxic activity ranged between 118 to 194 mg/mL against HT-29 cells. Fr.10 and Fr.11 showed no cytotoxic activity.Conclusion: Due to the inhibitory properties of extract and its fractions on cancer cells, identification of responsible compounds possessing cytotoxic effects for generating possible new approach in medicinal chemistry are recommended.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    SAJJADI, SEYED EBRAHIM, GHANADIAN, MUSTAFA, HAGHIGHI, MEHRANGIZ, & MOUHEBAT, LEILI. (2015). CYTOTOXIC EFFECT OF COUSINIA VERBASCIFOLIA BUNGE AGAINST OVCAR-3 AND HT-29 CANCER CELLS. JOURNAL OF HERBMED PHARMACOLOGY, 4(1), 15-19. SID. https://sid.ir/paper/343634/en

    Vancouver: Copy

    SAJJADI SEYED EBRAHIM, GHANADIAN MUSTAFA, HAGHIGHI MEHRANGIZ, MOUHEBAT LEILI. CYTOTOXIC EFFECT OF COUSINIA VERBASCIFOLIA BUNGE AGAINST OVCAR-3 AND HT-29 CANCER CELLS. JOURNAL OF HERBMED PHARMACOLOGY[Internet]. 2015;4(1):15-19. Available from: https://sid.ir/paper/343634/en

    IEEE: Copy

    SEYED EBRAHIM SAJJADI, MUSTAFA GHANADIAN, MEHRANGIZ HAGHIGHI, and LEILI MOUHEBAT, “CYTOTOXIC EFFECT OF COUSINIA VERBASCIFOLIA BUNGE AGAINST OVCAR-3 AND HT-29 CANCER CELLS,” JOURNAL OF HERBMED PHARMACOLOGY, vol. 4, no. 1, pp. 15–19, 2015, [Online]. Available: https://sid.ir/paper/343634/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button