ASSOCIATION OF THE PROMOTER METHYLATION OF MITOCHONDRIAL TRANSCRIPTION FACTOR A WITH SUSCEPTIBILITY TO METABOLIC SYNDROME

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HASHEMI MOHAMMAD; REZAI HAMZE; KAYKHAEI MAHMOUD ALI; TAHERI MOHSEN

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Journal: Gene, Cell and Tissue Year:2014 | Volume:1 | Issue:1 Page(s): 0-0

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Title

ASSOCIATION OF THE PROMOTER METHYLATION OF MITOCHONDRIAL TRANSCRIPTION FACTOR A WITH SUSCEPTIBILITY TO METABOLIC SYNDROME

Author(s)

HASHEMI MOHAMMAD | REZAI HAMZE | KAYKHAEI MAHMOUD ALI | TAHERI MOHSEN | Issue Writer Certificate

Keywords

METABOLIC SYNDROME X

MITOCHONDRIAL TRANSCRIPTION FACTOR A

DIABETES MELLITUS

TYPE 2 DM

Abstract

Background: It has been proposed that the patients with mitochondrial diseases usually manifest systemic metabolic disorders. The metabolic syndrome (MeS), a cluster of several metabolic disorders, is increasingly being recognized as a risk factor for type 2 diabetes (T2D) and cardiovascular disease.Objectives: The aim of study was to investigate the possible association between promoter methylation of MITOCHONDRIAL TRANSCRIPTION FACTOR A (TFAM) and MeS.Patients and Methods: DNA was extracted from peripheral blood of 151 patients with and 149 without MeS. Results: TFAM promoter methylation was evaluated by a nested methylation-specific PCR (nested MSP).Conclusions: No association was found between TFAM promoter methylation and MeS. The present study suggests that the TFAM promoter methylation is not associated with risk of MeS.

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APA: Copy

HASHEMI, MOHAMMAD, REZAI, HAMZE, KAYKHAEI, MAHMOUD ALI, & TAHERI, MOHSEN. (2014). ASSOCIATION OF THE PROMOTER METHYLATION OF MITOCHONDRIAL TRANSCRIPTION FACTOR A WITH SUSCEPTIBILITY TO METABOLIC SYNDROME. GENE, CELL AND TISSUE, 1(1), 0-0. SID. https://sid.ir/paper/345075/en

Vancouver: Copy

HASHEMI MOHAMMAD, REZAI HAMZE, KAYKHAEI MAHMOUD ALI, TAHERI MOHSEN. ASSOCIATION OF THE PROMOTER METHYLATION OF MITOCHONDRIAL TRANSCRIPTION FACTOR A WITH SUSCEPTIBILITY TO METABOLIC SYNDROME. GENE, CELL AND TISSUE[Internet]. 2014;1(1):0-0. Available from: https://sid.ir/paper/345075/en

IEEE: Copy

MOHAMMAD HASHEMI, HAMZE REZAI, MAHMOUD ALI KAYKHAEI, and MOHSEN TAHERI, “ASSOCIATION OF THE PROMOTER METHYLATION OF MITOCHONDRIAL TRANSCRIPTION FACTOR A WITH SUSCEPTIBILITY TO METABOLIC SYNDROME,” GENE, CELL AND TISSUE, vol. 1, no. 1, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/345075/en

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