THE EFFECTS OF PRECONDITIONING ON SURVIVAL OF MESENCHYMAL STEM CELLS IN VITRO

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FARZANEH TABAN ZAHRA; KHATIBI SHIVA; HALABIAN RAHELEH; MOHAMMADI ROUSHANDEH AMANEH

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Journal Paper

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Journal: Gene, Cell and Tissue Year:2016 | Volume:3 | Issue:4 Page(s): 0-0

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Title

THE EFFECTS OF PRECONDITIONING ON SURVIVAL OF MESENCHYMAL STEM CELLS IN VITRO

Author(s)

FARZANEH TABAN ZAHRA | KHATIBI SHIVA | HALABIAN RAHELEH | MOHAMMADI ROUSHANDEH AMANEH | Issue Writer Certificate

Keywords

MESENCHYMAL STEM CELL

PROLIFERATION

CELL SURVIVAL

PRECONDITIONING

Abstract

Background: MESENCHYMAL STEM CELLs (MSCs) survival decreased following in vivo injection and its application has been limited in stem cell therapy. PRECONDITIONING was established as a strategy to increase the cells’ efficiency, but more studies are necessary to determine its safety and mechanisms.Objectives: The aim of this study was to evaluate the effect of PRECONDITIONING MESENCHYMAL STEM CELLs with low serum and H2O2 on in vitro CELL SURVIVAL.Methods: MESENCHYMAL STEM CELLs were cultured and preconditioned with low serum and H2O2 for 6, 12, 24 and 48 hours in six groups. Control, group I with 5mM H2O2, group II with 10 mM H2O2, group III with 0.5% fetal bovine serum (FBS), group IV: 5 mM H2O2+0.5% FBS and V: 10 mMH2O2+0.5% FBS. Cell PROLIFERATION was evaluated with the MTT assay.Results: Cell PROLIFERATION in groups IV and V increased significantly compared to the other groups after 6, 12 and 24 hours of treatment (P<0.05). Also, after 48 hours, cell treatment with 5mMH2O2+0.5% FBS led to a significant increase in cell PROLIFERATION (P< 0.05).Conclusions: Our data suggest that PRECONDITIONING with 5MH2O2+0.5% FBS and 10mMH2O2+5% FBS improved cell PROLIFERATION and viability. However, the mechanisms related to protective properties of PRECONDITIONING and using this strategy in stem cell therapy requires more research.

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APA: Copy

FARZANEH TABAN, ZAHRA, KHATIBI, SHIVA, HALABIAN, RAHELEH, & MOHAMMADI ROUSHANDEH, AMANEH. (2016). THE EFFECTS OF PRECONDITIONING ON SURVIVAL OF MESENCHYMAL STEM CELLS IN VITRO. GENE, CELL AND TISSUE, 3(4), 0-0. SID. https://sid.ir/paper/345178/en

Vancouver: Copy

FARZANEH TABAN ZAHRA, KHATIBI SHIVA, HALABIAN RAHELEH, MOHAMMADI ROUSHANDEH AMANEH. THE EFFECTS OF PRECONDITIONING ON SURVIVAL OF MESENCHYMAL STEM CELLS IN VITRO. GENE, CELL AND TISSUE[Internet]. 2016;3(4):0-0. Available from: https://sid.ir/paper/345178/en

IEEE: Copy

ZAHRA FARZANEH TABAN, SHIVA KHATIBI, RAHELEH HALABIAN, and AMANEH MOHAMMADI ROUSHANDEH, “THE EFFECTS OF PRECONDITIONING ON SURVIVAL OF MESENCHYMAL STEM CELLS IN VITRO,” GENE, CELL AND TISSUE, vol. 3, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/345178/en

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