A survey of the Effects of Acquired Heart Diseases on Thyroid Hormones, Serum Biochemical and Hematological Indices in Dogs

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KHAKI Z.; MOHEBI P.; SHIRANI D.; JAMSHIDI SH.

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Journal: Journal of Veterinary Research Year:2018 | Volume:73 | Issue:1 Page(s): 111-118

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Title

A survey of the Effects of Acquired Heart Diseases on Thyroid Hormones, Serum Biochemical and Hematological Indices in Dogs

Author(s)

KHAKI Z. | MOHEBI P. | SHIRANI D. | JAMSHIDI SH. | Issue Writer Certificate

Keywords

Heart diseaseQ1

thyroid hormonesQ2

biochemical parametersQ1

troponinQ2

dogQ2

Abstract

BACKGROUND: A common problem encountered in veterinary medicine is the euthyroid sick syndrome(ESS(, which refers to a state where nonthyroidal illness(such as Heart diseases)causes suppression of serum concentrations of thyroid hormone without true pathology of the thyroid gland. Chronic valve disease (endocardiosis) is the most common cause of heart failure in dogs. About a third of small-breed dogs older than10 years of age are affected by Heart diseases, especially endocardiosis. OBJECTIVES: The aims of this study were to determine the effects of some acquired Heart diseases (endocardiosis, dilated cardiomyopathy and congestive heart failure) on thyroid hormones, some serum biochemical and hematological indices in small breed dogs. METHODS: A total of 50 small breed dogs were selected. 25 dogs were healthy and 15. 7 and 3 dogs had endocardiosis, congestive heart failure and dilated cardiomyopathy respectively which was confirmed by historical, physical examination, radiographic, and echocardiographic findings. thyroid hormones (T4, fT4andTSH) were determined by using commercial canine Elisa kits. Serum biochemical analysis was carried out to determine the levels of creatine phosphokinase, aspartate aminotransferase, troponin I, blood urea nitrogen, creatinine, total protein, albumin, globulin, triglycerides, and cholesterol. Also, Hematological indices (RBC, WBC, PCV, Hb and differential leukocyte count)were measured. RESULTS: One way ANOVA test showed that there were no significant changes in the serum levels of T4and fT4 in patients versus control group (p>0. 05), only TSH concentration in dilated cardiomyopathy dogs compared to other groups was significant (p<0. 05). Observations showed the creatine phosphokinase activity was significantly elevated in endocardiosis and congestive heart failure dogs in comparison with dilated cardiomyopathy and control groups. The serum concentration of protein was significantly decreased in congestive heart failure dogs compared with endocardiosis and control dogs. Also, in comparison with the control group, serum level of triglycerides was diminished in congestive heart failure dogs and blood urea nitrogen concentration was significantly increased in endocardiosis dogs compared with control. There were no significant differences in other biochemical and hematological parameters. CONCLUSIONS: In current study, euthyroid sick syndrome or hypothyroidism was not seen in small-breed dogs suffering from Heart disease. However, in dogs with endocardiosis, increase of serum creatine phosphokinase activity could be a symbol of complexity of Heart disease.

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APA: Copy

KHAKI, Z., MOHEBI, P., SHIRANI, D., & JAMSHIDI, SH.. (2018). A survey of the Effects of Acquired Heart Diseases on Thyroid Hormones, Serum Biochemical and Hematological Indices in Dogs. JOURNAL OF VETERINARY RESEARCH, 73(1 ), 111-118. SID. https://sid.ir/paper/34567/en

Vancouver: Copy

KHAKI Z., MOHEBI P., SHIRANI D., JAMSHIDI SH.. A survey of the Effects of Acquired Heart Diseases on Thyroid Hormones, Serum Biochemical and Hematological Indices in Dogs. JOURNAL OF VETERINARY RESEARCH[Internet]. 2018;73(1 ):111-118. Available from: https://sid.ir/paper/34567/en

IEEE: Copy

Z. KHAKI, P. MOHEBI, D. SHIRANI, and SH. JAMSHIDI, “A survey of the Effects of Acquired Heart Diseases on Thyroid Hormones, Serum Biochemical and Hematological Indices in Dogs,” JOURNAL OF VETERINARY RESEARCH, vol. 73, no. 1 , pp. 111–118, 2018, [Online]. Available: https://sid.ir/paper/34567/en

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