مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

555
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Effect of acute administration of Docosahexaenoic acid in mice drug resistance in 6Hz model of epilepsy

Pages

  491-498

Abstract

 BACKGROUND: Epilepsy is a chronic neurological disorder. Despite discovery of effective antiepileptic drugs (AEDs), more than 30% of patients are still resistant to AEDs. OBJECTIVES: Evaluation of the effect of acute administration of Docosahexaenoic acid (DHA) in mice resistant to antiepileptic drugs in 6Hz model of epilepsy. METHODS: At first intracerebroventricular (i. c. v) injection and oral consumption of DHA alone and intrapritoneal (i. p. ) injection of drugs in separate groups were evaluated. In test groups LTG 25 mg/kg or PHT 25mg/kg were injected i. p. 105 min after injection of PHT, 45 min after injection of LTG, DHA (1mM) was injected i. c. v. In control groups drugs solvent or DHA solvent was injected DHA. 15 min after injection of DHA or DHA solvent, in all groups 6 Hz stimulation was exerted and occurrence of limbic seizures was registered. In oral test groups PHT 25 mg/kg or LTG 25 mg/kg was injected i. p. 60 min after injection of PHT and simultaneous injection of LTG, DHA (0. 1 ml) was gavaged. 60 minutes after injection of DHA 6 Hz stimulation was exerted. RESULTS: Acute administration of DHA alone via i. c. v injection or oral gavage had no protective effect on inhibiting seizures. Administration of DHA with LTG or PHT also could not inhibit drug resistance. 6-Hz seizures when administered chronically. However, chronically administered DHA inhibited limbic seizures resistant to LTG and PHT. CONCLUSIONS: Acute administration of DHA could not inhibit resistance to LTG and phenytoin in 6-Hz model of epilepsy. Also, consumption of single dose of DHA with anticonvulsant drugs does not have any effect on prevention of drug resistance in epileptic patients.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    MOEZIFAR, M., SAYYAH, M., ZENDEHDEL, M., & BABAPOUR, V.. (2018). Effect of acute administration of Docosahexaenoic acid in mice drug resistance in 6Hz model of epilepsy. JOURNAL OF VETERINARY RESEARCH, 72(4 ), 491-498. SID. https://sid.ir/paper/34629/en

    Vancouver: Copy

    MOEZIFAR M., SAYYAH M., ZENDEHDEL M., BABAPOUR V.. Effect of acute administration of Docosahexaenoic acid in mice drug resistance in 6Hz model of epilepsy. JOURNAL OF VETERINARY RESEARCH[Internet]. 2018;72(4 ):491-498. Available from: https://sid.ir/paper/34629/en

    IEEE: Copy

    M. MOEZIFAR, M. SAYYAH, M. ZENDEHDEL, and V. BABAPOUR, “Effect of acute administration of Docosahexaenoic acid in mice drug resistance in 6Hz model of epilepsy,” JOURNAL OF VETERINARY RESEARCH, vol. 72, no. 4 , pp. 491–498, 2018, [Online]. Available: https://sid.ir/paper/34629/en

    Related Journal Papers

    Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops

  • No record.





    •  Move to top