Electrochemical Oxidation and Thermodynamic Parameters for an Anti-viral Drug Valacyclovir

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Devarushi Umesh S.; Shetti Nagaraj P.; Tuwar Suresh M.; Seetharamappa J.

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Journal: Analytical and Bioanalytical ElectroChemistry Year:2017 | Volume:9 | Issue:1 Page(s): 102-116

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Title

Electrochemical Oxidation and Thermodynamic Parameters for an Anti-viral Drug Valacyclovir

Author(s)

Devarushi Umesh S. | Shetti Nagaraj P. | Tuwar Suresh M. | Seetharamappa J. | Issue Writer Certificate

Keywords

Valacyclovir

Voltammetric techniques

Electrochemical studies

Oxidation thermodynamic parameters

Abstract

The electro-oxidation of Valacyclovir has been studied at a glassy carbon electrode in phosphate buffer media by using cyclic voltammetric technique. Effects of anodic peak potential (Epa), anodic peak current (ipa), pH and heterogeneous rate constant (ko) have been discussed, single irreversible voltammogram was observed. The effects of scan rate, pH, concentration and temperature were evaluated. The electrode processes were shown to be diffusion controlled and irreversible involving adsorption effects. The electro-oxidation product of Valacyclovir has been identified by MALDI2-((2-amine-6, 8-dioxo-7, 8-dihydro-3H-purin9(6H)-yl)methoxy)ethyl2-amino-3-methylbutanoate), involving 2-electron and 2-porton oxidation. Thermodynamic parameters such as activation energy Ea=27. 51 kJmol-1, enthalpy Δ H#=25. 03 kJmol-1, entropy Δ S#=-284. 8 JK-1mol-1, Gibbs free energy Δ G#=109. 9 kJmol-1 and Arrhenius factor, logA=-2. 08 and analytical parameters linearity range 5. 0×10-3 to 7. 5×10-5 M, LOD=1. 44 μ M, LOQ=4. 83 μ M and RSD=5. 26% were calculated and presented.

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APA: Copy

Devarushi, Umesh S., Shetti, Nagaraj P., Tuwar, Suresh M., & Seetharamappa, J.. (2017). Electrochemical Oxidation and Thermodynamic Parameters for an Anti-viral Drug Valacyclovir. ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY, 9(1), 102-116. SID. https://sid.ir/paper/346590/en

Vancouver: Copy

Devarushi Umesh S., Shetti Nagaraj P., Tuwar Suresh M., Seetharamappa J.. Electrochemical Oxidation and Thermodynamic Parameters for an Anti-viral Drug Valacyclovir. ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY[Internet]. 2017;9(1):102-116. Available from: https://sid.ir/paper/346590/en

IEEE: Copy

Umesh S. Devarushi, Nagaraj P. Shetti, Suresh M. Tuwar, and J. Seetharamappa, “Electrochemical Oxidation and Thermodynamic Parameters for an Anti-viral Drug Valacyclovir,” ANALYTICAL & BIOANALYTICAL ELECTROCHEMISTRY, vol. 9, no. 1, pp. 102–116, 2017, [Online]. Available: https://sid.ir/paper/346590/en

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