مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PREVALENCE OF EXTENDED SPECTRUM β-LACTAMASE, AMPC β-LACTAMASE AND METALLO-β-LACTAMASE AMONG GRAM NEGATIVE BACILLI RECOVERED FROM CLINICAL SPECIMENS IN BENIN CITY, NIGERIA

Pages

  85-91

Keywords

EXTENDED SPECTRUM BETA-LACTAMASE (ESBL) 

Abstract

 Background: Multidrug resistant BACTERIA continue to be a bane in the treatment of clinical infections in Nigeria. Knowledge of trends in resistance mechanisms is vital in determining available therapeutic options.Objective: This study was aimed at determining the prevalence, distribution and antimicrobial susceptibility of extended spectrum b-lactamase (ESBL), AmpC b-lactamase and metallo-b-lactamase (MBL) -producing gram negative BACTERIA (GNB) recovered from clinical specimens in a tertiary hospital in Southern Nigeria.Materials and Methods: A total of 309 consecutive non-repetitive clinical BACTERIAl isolates were recovered from various clinical specimens. The presence of ESBL, AmpC b-lactamase and MBL as well as the susceptibility profiles were determined using standard microbiological techniques.Results: ESBL was the most prevalent (P<0.0001) of the 3 enzymes detected in this study. BACTERIAl isolates recovered from inpatients had a higher likelihood of producing ESBL than those recovered from out-patients (odds ratio [OR] =2.225, 95% CI=1.375, 3.599; P=0.0015). The highest prevalence of ESBL, AmpC and MBL enzyme was observed for Providencia species, Pseudomonas aeruginosa and Citrobacter species respectively. b-Lactamase positive isolates showed poor activity against cephalosporin, amoxicillin-clavulanate, gentamicin and the fluoroquinolones. Isolates that produced any of the three b-lactamase enzymes showed more resistance to antibacterial drugs than b-lactamase negative BACTERIAl isolates.Conclusion: A prevalence of 41.7%, 15.2% and 28.5% was observed for ESBL, AmpC b-lactamase and MBL respectively in this study. Isolates that produced any of the enzymes were more resistant to antibacterial agents. Prudence in antibiotic use is strongly advocated.

Cites

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    • Cite

    APA: Copy

    EHIDIAMEN IBADIN, EPHRAIM, OMOREGIE, RICHARD, OHIORENUAN IGBARUMAH, ISAAC, ATINUKE ANOGIE, NANA, & OROBOGHAE OGEFERE, HELEN. (2017). PREVALENCE OF EXTENDED SPECTRUM β-LACTAMASE, AMPC β-LACTAMASE AND METALLO-β-LACTAMASE AMONG GRAM NEGATIVE BACILLI RECOVERED FROM CLINICAL SPECIMENS IN BENIN CITY, NIGERIA. INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN, 5(3), 85-91. SID. https://sid.ir/paper/347587/en

    Vancouver: Copy

    EHIDIAMEN IBADIN EPHRAIM, OMOREGIE RICHARD, OHIORENUAN IGBARUMAH ISAAC, ATINUKE ANOGIE NANA, OROBOGHAE OGEFERE HELEN. PREVALENCE OF EXTENDED SPECTRUM β-LACTAMASE, AMPC β-LACTAMASE AND METALLO-β-LACTAMASE AMONG GRAM NEGATIVE BACILLI RECOVERED FROM CLINICAL SPECIMENS IN BENIN CITY, NIGERIA. INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN[Internet]. 2017;5(3):85-91. Available from: https://sid.ir/paper/347587/en

    IEEE: Copy

    EPHRAIM EHIDIAMEN IBADIN, RICHARD OMOREGIE, ISAAC OHIORENUAN IGBARUMAH, NANA ATINUKE ANOGIE, and HELEN OROBOGHAE OGEFERE, “PREVALENCE OF EXTENDED SPECTRUM β-LACTAMASE, AMPC β-LACTAMASE AND METALLO-β-LACTAMASE AMONG GRAM NEGATIVE BACILLI RECOVERED FROM CLINICAL SPECIMENS IN BENIN CITY, NIGERIA,” INTERNATIONAL JOURNAL OF ENTERIC PATHOGEN, vol. 5, no. 3, pp. 85–91, 2017, [Online]. Available: https://sid.ir/paper/347587/en

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