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Information Journal Paper

Title

Designing a Label Free Aptasensor for Detection of Methamphetamine

Pages

  28-33

Abstract

 A label-free electrochemical nucleic acid Aptasensor for the detection of Methamphetamine (MA) by the immobilization of thiolated self-assembled DNA sequences on a gold nanoparticles-chitosan modified electrode is constructed. When MA was complexed specifically to the aptamer, the configuration of the nucleic acid aptamer switched to a locked structure and the interface of the biosensor changed, resulting in a variation of the corresponding peak current of an electrochemical probe ([Fe(CN)6]3-/4-). Two different methods of cyclic voltammetry (CV) and microcantilever were employed to determine MA Detection limit. Under the optimized experimental conditions, the presented sensor exhibits a nice specificity towards MA. The Detection limits for MA in electrode and microcantilever were obtained 10 and 0. 7 nM. The proposed Aptasensor can be easily regenerated by the denaturalization of aptamer-target complexes in a heated water bath at 80-90 ° C. Besides, this biosensor has a high reproducibility and selectivity, which can be a promising method to detect MA in real samples.

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    • Cite

    APA: Copy

    Kohzadi, R., MOLAEIRAD, A., ALIJANIANZADEH, M., KAMALI, N., & Mohtashamifar, M.. (2016). Designing a Label Free Aptasensor for Detection of Methamphetamine. BIOMACROMOLECULAR JOURNAL, 2(1), 28-33. SID. https://sid.ir/paper/348369/en

    Vancouver: Copy

    Kohzadi R., MOLAEIRAD A., ALIJANIANZADEH M., KAMALI N., Mohtashamifar M.. Designing a Label Free Aptasensor for Detection of Methamphetamine. BIOMACROMOLECULAR JOURNAL[Internet]. 2016;2(1):28-33. Available from: https://sid.ir/paper/348369/en

    IEEE: Copy

    R. Kohzadi, A. MOLAEIRAD, M. ALIJANIANZADEH, N. KAMALI, and M. Mohtashamifar, “Designing a Label Free Aptasensor for Detection of Methamphetamine,” BIOMACROMOLECULAR JOURNAL, vol. 2, no. 1, pp. 28–33, 2016, [Online]. Available: https://sid.ir/paper/348369/en

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