THE EFFECT OF DEXAMETHASONE TO PREVENT INDUCED LUTEOLYSIS IN HOLSTEIN HEIFER

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MOHAMMAD SADEGH M.; HOVARESHTI P.; BOLURCHI M.; BOKAEI S.; NOUROUZIAN I.

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Journal: Journal of Veterinary Research Year:2003 | Volume:58 | Issue:2 Page(s): 111-114

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Title

THE EFFECT OF DEXAMETHASONE TO PREVENT INDUCED LUTEOLYSIS IN HOLSTEIN HEIFER

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Keywords

DEXAMETHASONEQ3

DINAPROSTQ4

PGF2ΑQ4

INDUCTION OF LUTEOLYSISQ4

INHIBITION OF LUTEOLYSISQ4

Abstract

Objective: Study the effect of DEXAMETHASONE to inhibit induced corpus luteal regression with PGF2Α treatment. Design: Clinical trail (Replacement treatment design) Animals: Seventeen Holstein heifers at 15- 17 month of age and 340kg mean body weight. Treatment: 1-DEXAMETHASONE (I5 mg, Im, Colvasone, Nor broke Co. England). 2- PGF2Α (25 mg, Im, Lutalyse, Upjohn Co. USA) Procedure: The numbers, of animals showing lutolysis after the injection of PGF2Α on day 9 of synchronized estrous cycle (control group) were estimated and then, on the following estrous cycle, the numbers of animals showing lutolysis after the injection of DEXAMETHASONE on day 8, and PGF2Α on day 9 (test group) were estimated. Blood samples were collected on day 8 and 13 of the cycle to assay serum progesterone levels and demonstrate the activity of CL. Estrous detection and rectal polpation of corpus luteum were established through day 8 to 13 of the cycle. Statistical analysis: Fisher exact (two tailed) test. Results: Corpora lutea of 17 animals of control group (100%) were regressed after the injection of the PGF2Α but CLs of 6 animals of test group (35.3%) were not regressed. The injection of DEXAMETHASONE, 24h before the INDUCTION OF LUTEOLYSIS with PGF2Α on day 9 of the estrous cycle significantly inhibited lutolysis (P >0.05). Clinical Implications: it seems that luteolysis effect of PGF2Α which is needed in the case of estrous synchronization and/or uterine injection, may be impaired in treated animal with DEXAMETHASONE as an anti -anti-inflammatory amatory drug

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APA: Copy

NOUROUZIAN, I., MOHAMMAD SADEGH, M., HOVARESHTI, P., BOLURCHI, M., & BOKAEI, S.. (2003). THE EFFECT OF DEXAMETHASONE TO PREVENT INDUCED LUTEOLYSIS IN HOLSTEIN HEIFER. JOURNAL OF VETERINARY RESEARCH, 58(2), 111-114. SID. https://sid.ir/paper/34891/en

Vancouver: Copy

NOUROUZIAN I., MOHAMMAD SADEGH M., HOVARESHTI P., BOLURCHI M., BOKAEI S.. THE EFFECT OF DEXAMETHASONE TO PREVENT INDUCED LUTEOLYSIS IN HOLSTEIN HEIFER. JOURNAL OF VETERINARY RESEARCH[Internet]. 2003;58(2):111-114. Available from: https://sid.ir/paper/34891/en

IEEE: Copy

I. NOUROUZIAN, M. MOHAMMAD SADEGH, P. HOVARESHTI, M. BOLURCHI, and S. BOKAEI, “THE EFFECT OF DEXAMETHASONE TO PREVENT INDUCED LUTEOLYSIS IN HOLSTEIN HEIFER,” JOURNAL OF VETERINARY RESEARCH, vol. 58, no. 2, pp. 111–114, 2003, [Online]. Available: https://sid.ir/paper/34891/en

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