مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

142
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

59
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

CYP2C19 Genetic Polymorphism in the East of Iran: It's Association with the Severity and Pattern of Coronary Artery Disease

Author(s)

 ZAHEDI MAHDI | MOHAMMADZADEH SHABESTARI MAHMOUD | AYATOLLAHI HOSSEIN | GHOLOOBI ARASH | Issue Writer Certificate 

Pages

  417-421

Abstract

 Introduction: Since there has been a dearth of research on the assessment of CYP2C19 Polymorphism in the east of Iran (Khorasan provinces), this study aimed to detect, CYP2C19*2 and CYP2C19*3 allele frequencies among patients with Coronary Artery Disease. The participants were selected among those referring to Emam Reza Hospital, Mashhad, Iran. Furthermore, the current research was motivated to elucidate the association of CYP2C19 Polymorphism with the severity and pattern of Coronary Artery Disease. Material and Methods: This study was conducted on 84 patients who were subjected selective coronary angiography. The participants of the present study were from Khorasan, Iran. The Genotyping of extracted crude DNA for CYP2C19*2 (rs4244285) and CYP2C19*3 (rs4986893) alleles was performed through PCR-RFLP method. Results: The obtained results of the current study revealed three different allelic band patterns. Out of the 84 individuals, 71 were homozygous for the wild type allele in both exon 5 and exon 4 (wt/wt; 84. 5%), 15 were homozygous for the CYP2C19*2 polymorphism (*2/*2; 14. 3%), and 1 subject was homozygous for the CYP2C19*3 (*3/*3; 1. 2%). No subjects were heterozygous for the CYP2C19*2 (wt/*2; 0. 0%) or CYP2C19*3 (wt/*3; 0. 0%) or heterozygous for the CYP2C19*2 and the CYP2C19*3 mutations (*2/*3; 0. 0%). Conclusion: The findings of the current study confirmed the existence of CYP2C19 Polymorphism among people of Khorasan.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    ZAHEDI, MAHDI, MOHAMMADZADEH SHABESTARI, MAHMOUD, AYATOLLAHI, HOSSEIN, & GHOLOOBI, ARASH. (2019). CYP2C19 Genetic Polymorphism in the East of Iran: It's Association with the Severity and Pattern of Coronary Artery Disease. JOURNAL OF CARDIO THORACIC MEDICINE, 7(1), 417-421. SID. https://sid.ir/paper/349875/en

    Vancouver: Copy

    ZAHEDI MAHDI, MOHAMMADZADEH SHABESTARI MAHMOUD, AYATOLLAHI HOSSEIN, GHOLOOBI ARASH. CYP2C19 Genetic Polymorphism in the East of Iran: It's Association with the Severity and Pattern of Coronary Artery Disease. JOURNAL OF CARDIO THORACIC MEDICINE[Internet]. 2019;7(1):417-421. Available from: https://sid.ir/paper/349875/en

    IEEE: Copy

    MAHDI ZAHEDI, MAHMOUD MOHAMMADZADEH SHABESTARI, HOSSEIN AYATOLLAHI, and ARASH GHOLOOBI, “CYP2C19 Genetic Polymorphism in the East of Iran: It's Association with the Severity and Pattern of Coronary Artery Disease,” JOURNAL OF CARDIO THORACIC MEDICINE, vol. 7, no. 1, pp. 417–421, 2019, [Online]. Available: https://sid.ir/paper/349875/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button