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Information Journal Paper

Title

THE EFFECTS OF OLIVE LEAF EXTRACT ADMINISTRATION ON THE CEREBRAL HYPOPERFUSION-INDUCED ELECTROPHYSIOLOGICAL ALTERATIONS IN RAT HEART

Pages

  105-113

Abstract

 Background and Aim: In the present study, the role of ethanolic extract of olive (Olea europaea) leaf administration against the CEREBRAL HYPOPERFUSION-induced electrophysiological alterations and left ventricular thickness in rat heart was studied.Materials and Methods: The right carotid artery was occluded with a 5-0 silk suture and the left carotid artery was occluded after a week. The olive (Olea europaea) leaf extract was administered orally (by gavage) to three experimental groups of rats in 100, 200 and 300 mg/kg/day for two weeks after the left carotid artery occlusion and processed in 25 days. The sham and hypoperfusion groups were fed with normal saline. Each group had 6 rats. After 25 days, electrophysiological heart parameters, i.e. HR, QTc, QRS duration, QT interval, PR interval, RR interval, ST amplitude, T wave amplitude and also the thickness of LEFT VENTRICLE (TLV) were assessed.Results: The administration of OLIVE LEAF EXTRACT (100, 200 and 300 mg/kg) exhibited its cardioprotective effect by both stabilizing heart rate and preventing ECG changes (such as shortening of PR, QRS, QT and QTc intervals, prominent T waves and ST elevation). Moreover, OLIVE LEAF EXTRACT (100, 200 and 300 mg/kg) prevented cardiac hypertrophy after CEREBRAL HYPOPERFUSION.Conclusion: Our results indicated that post-treatment with ethanolic extract of olive leaves could prove beneficial effects in managing the CEREBRAL HYPOPERFUSION-induced cardiac abnormality in rats.

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    APA: Copy

    MOGHADDASI, MEHRNOUSH, TAATI, MAJID, NOROOZI, HASAN, BAMANI LIRGESHASI, SAM, POURKHODADAD, SOHEILA, DELFAN, BAHRAM, & NAZARI, AFSHIN. (2017). THE EFFECTS OF OLIVE LEAF EXTRACT ADMINISTRATION ON THE CEREBRAL HYPOPERFUSION-INDUCED ELECTROPHYSIOLOGICAL ALTERATIONS IN RAT HEART. HERBAL MEDICINES JOURNAL, 2(3 ), 105-113. SID. https://sid.ir/paper/351299/en

    Vancouver: Copy

    MOGHADDASI MEHRNOUSH, TAATI MAJID, NOROOZI HASAN, BAMANI LIRGESHASI SAM, POURKHODADAD SOHEILA, DELFAN BAHRAM, NAZARI AFSHIN. THE EFFECTS OF OLIVE LEAF EXTRACT ADMINISTRATION ON THE CEREBRAL HYPOPERFUSION-INDUCED ELECTROPHYSIOLOGICAL ALTERATIONS IN RAT HEART. HERBAL MEDICINES JOURNAL[Internet]. 2017;2(3 ):105-113. Available from: https://sid.ir/paper/351299/en

    IEEE: Copy

    MEHRNOUSH MOGHADDASI, MAJID TAATI, HASAN NOROOZI, SAM BAMANI LIRGESHASI, SOHEILA POURKHODADAD, BAHRAM DELFAN, and AFSHIN NAZARI, “THE EFFECTS OF OLIVE LEAF EXTRACT ADMINISTRATION ON THE CEREBRAL HYPOPERFUSION-INDUCED ELECTROPHYSIOLOGICAL ALTERATIONS IN RAT HEART,” HERBAL MEDICINES JOURNAL, vol. 2, no. 3 , pp. 105–113, 2017, [Online]. Available: https://sid.ir/paper/351299/en

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