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Information Journal Paper

Title

THE EFFECT OF TRANSPLANTED HUMAN WHARTON’S JELLY MESENCHYMAL STEM CELLS ON MATRIX METALLOPROTEINASES IN BRAIN OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MICE

Pages

  553-557

Abstract

 MESENCHYMAL STEM CELLS (MSCs) have immunosuppressive and anti-inflammatoryproperties and thus offer a potentially attractive therapeutic option for autoimmunediseases such as multiple sclerosis (MS). MATRIX METALLOPROTEINASES (MMPs) are afamily of extracellular enzymes that play a key role in the pathogenesis of MS. It isunclear whether MSCs affect MMPs or not. In this study, we evaluated the effect ofHuman Wharton’s Jelly MESENCHYMAL STEM CELLS (hWJ-MSCs) on gene expressionof MMPs in mice with EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE). Weisolated hWJ-MSCs based on explant culture. HWJ-MSCs were injected on days 3and 11 after EAE induction. In the peak phase of disease (day 22) and 50 days afterEAE induction, the brains were harvested and the expression of MMP-2, MMP-9,and tissue inhibitor of metalloproteinases-1 (TIMP-1) genes in brain of EAE micewas studied. HWJ-MSCs significantly decreased the expression of MMP-2 andMMP-9 genes but increased gene expression of TIMP-1 in brain of EAE mice. Ourfinding open new perspectives for understanding the mechanisms of MSCs intreatment of MS.

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    Cite

    APA: Copy

    SALIMI, ALI, AMARI, AFSHIN, GHOLLASI, MARZIEH, & NOROUZ, FAEZEH. (2017). THE EFFECT OF TRANSPLANTED HUMAN WHARTON’S JELLY MESENCHYMAL STEM CELLS ON MATRIX METALLOPROTEINASES IN BRAIN OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MICE. JOURNAL OF APPLIED BIOTECHNOLOGY REPORTS, 4(1), 553-557. SID. https://sid.ir/paper/352950/en

    Vancouver: Copy

    SALIMI ALI, AMARI AFSHIN, GHOLLASI MARZIEH, NOROUZ FAEZEH. THE EFFECT OF TRANSPLANTED HUMAN WHARTON’S JELLY MESENCHYMAL STEM CELLS ON MATRIX METALLOPROTEINASES IN BRAIN OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MICE. JOURNAL OF APPLIED BIOTECHNOLOGY REPORTS[Internet]. 2017;4(1):553-557. Available from: https://sid.ir/paper/352950/en

    IEEE: Copy

    ALI SALIMI, AFSHIN AMARI, MARZIEH GHOLLASI, and FAEZEH NOROUZ, “THE EFFECT OF TRANSPLANTED HUMAN WHARTON’S JELLY MESENCHYMAL STEM CELLS ON MATRIX METALLOPROTEINASES IN BRAIN OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS MICE,” JOURNAL OF APPLIED BIOTECHNOLOGY REPORTS, vol. 4, no. 1, pp. 553–557, 2017, [Online]. Available: https://sid.ir/paper/352950/en

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