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Information Journal Paper

Title

Association Between MspI Polymorphisms of the Apolipoprotein A-I Gene and Hyperlipidemia in an Iranian Population

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Abstract

 Background: One of the most important metabolic disorders is Hyperlipidemia. ApoAI protein plays an important role in lipoprotein metabolism. In this study, the association between MspI polymorphisms in the promoter (G-75A) and first intron (C83T) of the apoAI gene and Hyperlipidemia was investigated in Semnan, Iran. Methods: A total of 151 unrelated subjects were divided into two groups: the Hyperlipidemic (N = 75) and control (N = 76) groups. Genotyping was carried out by polymerase chain reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: In the Hyperlipidemic group, the frequency of the (+-) variant of the MspI (C83T) locus was higher than that in the control group (P < 0. 05). Significant differences were found in serum HDL-C and apoAI levels between different genotypes of MspI (C83T) (P < 0. 001 and P = 0. 02, respectively). In the Hyperlipidemic group, the odds ratios for the (+-) and (– ) genotypes of the MspI (C83T) locus in comparison to that for the (++) genotype were 0. 26 (P= 0. 023) and 3. 62 (P = 0. 254), respectively. The allelic frequency at the (G-75A) locus was not significantly different in the Hyperlipidemic and control groups (P = 0. 36). The serum levels of lipid and lipoprotein were not significantly different for all genotypes of MspI (G-75A). The AA/++ and GG/– haplotypes had the lowest and highest apoB/apoAI ratios, respectively (0. 73 0. 03 vs. 1. 9). Conclusions: The presence of (+) and A alleles in the apoAI (C83T) and (G-75A) haplotypes in the Semnan population may be protective against cardiovascular disease.

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    APA: Copy

    PAKDEL, ABBAS, AKBARI EIDGAHI, MOHAMMAD REZA, & Bandegi, Ahmad R.. (2018). Association Between MspI Polymorphisms of the Apolipoprotein A-I Gene and Hyperlipidemia in an Iranian Population. MIDDLE EAST JOURNAL OF REHABILITATION AND HEALTH STUDIES, 5(1), 0-0. SID. https://sid.ir/paper/354838/en

    Vancouver: Copy

    PAKDEL ABBAS, AKBARI EIDGAHI MOHAMMAD REZA, Bandegi Ahmad R.. Association Between MspI Polymorphisms of the Apolipoprotein A-I Gene and Hyperlipidemia in an Iranian Population. MIDDLE EAST JOURNAL OF REHABILITATION AND HEALTH STUDIES[Internet]. 2018;5(1):0-0. Available from: https://sid.ir/paper/354838/en

    IEEE: Copy

    ABBAS PAKDEL, MOHAMMAD REZA AKBARI EIDGAHI, and Ahmad R. Bandegi, “Association Between MspI Polymorphisms of the Apolipoprotein A-I Gene and Hyperlipidemia in an Iranian Population,” MIDDLE EAST JOURNAL OF REHABILITATION AND HEALTH STUDIES, vol. 5, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/354838/en

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