FLORFENICOLPHARMACOKINETICS IN CALVES FOLLOWINGASINGLE SUBCUTANEOUS INJECTION

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RASSOULI A.; LEES P.; SIDHU P.

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Journal: Journal of Veterinary Research Year:2011 | Volume:66 | Issue:2 Page(s): 95-101

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Information Journal Paper

Title

FLORFENICOLPHARMACOKINETICS IN CALVES FOLLOWINGASINGLE SUBCUTANEOUS INJECTION

Author(s)

RASSOULI A. | LEES P. | SIDHU P. | Issue Writer Certificate

Keywords

FLORFENICOLQ2

PHARMACOKINETICSQ2

PK-PD INTEGRATIONQ2

CALFQ2

HPLCQ3

Abstract

This study was a part of a larger project using pharmacokinetic-pharmacodynamic (PK-PD) modelling to evaluate antimicrobial drugs in CALF pneumonia. Ten healthy animals received 40 mg/kg FLORFENICOL by a single subcutaneous (SC) injection and at pre-determined time points (0-120 h), serum, exudate and transudate samples were collected using a tissue cage model.FLORFENICOL concentrations in samples were determined by a validated HPLC method and then PK parameters of FLORFENICOL in biological fluids of calves were calculated. FLORFENICOL PK data were used for PK-PD INTEGRATION and for determination of average concentrations/minimal inhibitory concentration (Cave/MIC) ratios of M. hemolytica and P. multocida in 24 h periods following injection. In PK modelling, a two-compartmental model for serum and a one-compartmental model for exudate and transudate were used. Comparing the PK parameters of three biological fluids indicated that mean serum C max (5.91 mg/ml) was higher and mean serum T max (2.28 h) was much shorter than those of exudate (3.39 mg/ml, 17.2 h) and transudate (2.84 mg/ml, 17.9 h).These results suggest that FLORFENICOL readily penetrates and distributes in interstitial fluids and achieves concentrations about half of the serum levels in tissue cage fluids. PK- PD integration of FLORFENICOL in serum of calves showed desirable values for AUC 0-24 h/MIC in M. hemolytica andP. multocida, 151.8 and 183.3 h, respectively and T>MIC was at least 72 h. In conclusion, FLORFENICOL therapeutic concentration in calves is achieved at least for 72 h by a single SC injection, though the efficacy of this dosage regimen in CALF pneumonia should be confirmed in clinical field trials.

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APA: Copy

RASSOULI, A., LEES, P., & SIDHU, P.. (2011). FLORFENICOLPHARMACOKINETICS IN CALVES FOLLOWINGASINGLE SUBCUTANEOUS INJECTION. JOURNAL OF VETERINARY RESEARCH, 66(2), 95-101. SID. https://sid.ir/paper/35529/en

Vancouver: Copy

RASSOULI A., LEES P., SIDHU P.. FLORFENICOLPHARMACOKINETICS IN CALVES FOLLOWINGASINGLE SUBCUTANEOUS INJECTION. JOURNAL OF VETERINARY RESEARCH[Internet]. 2011;66(2):95-101. Available from: https://sid.ir/paper/35529/en

IEEE: Copy

A. RASSOULI, P. LEES, and P. SIDHU, “FLORFENICOLPHARMACOKINETICS IN CALVES FOLLOWINGASINGLE SUBCUTANEOUS INJECTION,” JOURNAL OF VETERINARY RESEARCH, vol. 66, no. 2, pp. 95–101, 2011, [Online]. Available: https://sid.ir/paper/35529/en

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