EFFECTS OF LONG TERM PERINATAL ADMINISTRATION OF BUPROPION ON POPULATION SPIKE AMPLITUDE IN NEONATAL RAT HIPPOCAMPAL SLICES

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HEYSIAT TALAB S.; ZARE SAMAD; GHADERI PAKDEL F.

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Journal: Koomesh Year:2010 | Volume:11 | Issue:4 (36) Page(s): 287-294

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Title

EFFECTS OF LONG TERM PERINATAL ADMINISTRATION OF BUPROPION ON POPULATION SPIKE AMPLITUDE IN NEONATAL RAT HIPPOCAMPAL SLICES

Author(s)

HEYSIAT TALAB S. | ZARE SAMAD | GHADERI PAKDEL F. | Issue Writer Certificate

Keywords

BUPROPIONQ2

HIPPOCAMPAL SLICEQ3

POPULATION SPIKEQ3

RATQ4

Abstract

Introduction: The perinatal effects of antidepressants on CNS due to its common usage are important issues in neuroscience research. BUPROPION is an atypical antidepressant that is used in smoke cessation under FDA approve widely. The study of synaptic effects of BUPROPION can reveal its mechanism for nicotine dependence cessation. In this study the long term effects of perinatal BUPROPION on POPULATION SPIKE (PS) amplitudes were investigated. The PS amplitude is a good parameter for synaptic plasticity. Materials and Methods: HIPPOCAMPAL SLICEs from 18-25 day old RAT’s pups were prepared. The exam groups included control and BUPROPION treated groups. BUPROPION (40 mg/Kg, i.p) was applied in perinatal period daily as pretreatment. BUPROPION also was perfused in ACSF (10, 50, 200 mmol, 30 minutes) and tested for PS amplitude. PS amplitude of Stratum Radiatum was measured before and after BUPROPION perfusion. Amplitude of PS before BUPROPION perfusion was fitted as 100% for baseline. Results: A concentration of 10 mM did not reduce PS amplitude and BUPROPION had no significant effects on PS amplitude. BUPROPION in concentration of 50mM could reduce the amplitude of responses in 50% of cases. The 200 mM of BUPROPION perfusion reduced POPULATION SPIKE amplitude all slices (n=22). In the last state POPULATION SPIKE amplitude in 8 out 0f 22 slices completely abolished. Decrease POPULATION SPIKE amplitude in non-treated slices with 200 mM perfusion was more than treated slices. Conclusion: Analyzing of data showed that chronic perinatal exposure to BUPROPION in concentrations 50, 200 mM reduced PS amplitude and we found adaptation synaptic in perfusion 200 mM compare with BUPROPION treated slices with non- treated.

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APA: Copy

HEYSIAT TALAB, S., ZARE, SAMAD, & GHADERI PAKDEL, F.. (2010). EFFECTS OF LONG TERM PERINATAL ADMINISTRATION OF BUPROPION ON POPULATION SPIKE AMPLITUDE IN NEONATAL RAT HIPPOCAMPAL SLICES. KOOMESH, 11(4 (36)), 287-294. SID. https://sid.ir/paper/356137/en

Vancouver: Copy

HEYSIAT TALAB S., ZARE SAMAD, GHADERI PAKDEL F.. EFFECTS OF LONG TERM PERINATAL ADMINISTRATION OF BUPROPION ON POPULATION SPIKE AMPLITUDE IN NEONATAL RAT HIPPOCAMPAL SLICES. KOOMESH[Internet]. 2010;11(4 (36)):287-294. Available from: https://sid.ir/paper/356137/en

IEEE: Copy

S. HEYSIAT TALAB, SAMAD ZARE, and F. GHADERI PAKDEL, “EFFECTS OF LONG TERM PERINATAL ADMINISTRATION OF BUPROPION ON POPULATION SPIKE AMPLITUDE IN NEONATAL RAT HIPPOCAMPAL SLICES,” KOOMESH, vol. 11, no. 4 (36), pp. 287–294, 2010, [Online]. Available: https://sid.ir/paper/356137/en

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