ACUTE TOXICITY EFFECT OF DIAZINON ON ANTIOXIDANT SYSTEM AND LIPID PEROXIDATION IN KIDNEY TISSUES OF RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ABBASNEJAD MARYAM; JAFARI MAHVASH; ASGARI A.R.; HAJI HOSSEINI REZA; HAJI GHOLAMALI M.; SALEHI MARYAM; SALIMIAN M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2009 | Volume:16 | Issue:83 Page(s): 0-0

Download Full-Text

Persian Verion

View:

1,102

Download:

Cites:

Information Journal Paper

Title

ACUTE TOXICITY EFFECT OF DIAZINON ON ANTIOXIDANT SYSTEM AND LIPID PEROXIDATION IN KIDNEY TISSUES OF RATS

Author(s)

Keywords

DIAZINONQ2

KIDNEYQ2

ANTIOXIDANT SYSTEMQ3

LIPID PEROXIDATIONQ3

RATQ2

Abstract

Background and Objective: DIAZINON is one of the most widely used organophosphates (OPs) in agriculture. Toxic effects of DIAZINON are due to the inhibition of acetylcolinesterase, an enzyme needed for proper nervous system function. Investigates show that different classes of Ops may induce the production of free radicals and in cause disturbance in body ANTIOXIDANT SYSTEMs. The purpose of this study was to evaluate the effects of DIAZINON on oxidant-antioxidant system in the KIDNEY of RAT. Materials and Methods: Wistar male RATs were randomly divided into four groups including: control (corn oil as DIAZINON solvent) and three groups of DIAZINON receiving different doeses (30, 50 and 100 mg/kg) by intraperitoneal injection. 24 hours after injection, the RATs to ether anesthesia and the KIDNEY tissue was removed. The hemogenation, superoxide dismutase (SOD), catalase (CAT), lactate dehydrogenase (LDH), glutathione S-transferase (GST) activities, glutathione (GSH) and malondialdehyde (MDA) levels were determined through biochemical methods. Results: The enhanced activities of CAT and SOD at doses higher than 30 mg/kg DIAZINON, and the increased MDA level at 100 mg/kg dose were observed; whereas, the GSH level was significantly decreased comparing to the control group.No significant changes were observed with regard to GST and LDH activities. Conclusion: DIAZINON induces the production of free radicals and oxidative stress. The enhanced activity of antioxidant enzymes and depleted GSH content is indicative of oxidative tissue injury.

Cites

No record.

References

No record.

Cite

APA: Copy

ABBASNEJAD, MARYAM, JAFARI, MAHVASH, ASGARI, A.R., HAJI HOSSEINI, REZA, HAJI GHOLAMALI, M., SALEHI, MARYAM, & SALIMIAN, M.. (2009). ACUTE TOXICITY EFFECT OF DIAZINON ON ANTIOXIDANT SYSTEM AND LIPID PEROXIDATION IN KIDNEY TISSUES OF RATS. DANESHVAR MEDICINE, 16(83), 0-0. SID. https://sid.ir/paper/356367/en

Vancouver: Copy

ABBASNEJAD MARYAM, JAFARI MAHVASH, ASGARI A.R., HAJI HOSSEINI REZA, HAJI GHOLAMALI M., SALEHI MARYAM, SALIMIAN M.. ACUTE TOXICITY EFFECT OF DIAZINON ON ANTIOXIDANT SYSTEM AND LIPID PEROXIDATION IN KIDNEY TISSUES OF RATS. DANESHVAR MEDICINE[Internet]. 2009;16(83):0-0. Available from: https://sid.ir/paper/356367/en

IEEE: Copy

MARYAM ABBASNEJAD, MAHVASH JAFARI, A.R. ASGARI, REZA HAJI HOSSEINI, M. HAJI GHOLAMALI, MARYAM SALEHI, and M. SALIMIAN, “ACUTE TOXICITY EFFECT OF DIAZINON ON ANTIOXIDANT SYSTEM AND LIPID PEROXIDATION IN KIDNEY TISSUES OF RATS,” DANESHVAR MEDICINE, vol. 16, no. 83, pp. 0–0, 2009, [Online]. Available: https://sid.ir/paper/356367/en

Related Journal Papers