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Information Journal Paper

Title

ANTIOXIDANT EFFECTS OF BETAINE AGAINST INDOMETHACIN-INDUCED GASTRIC DAMAGE IN RATS

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Abstract

 Introduction: BETAINE (trimethyl glycine) is known as methyl group donor and antioxidant in previous reports. The aim of this study was to assess the antioxidant effects of BETAINE in Indomethacin-induced gastric damages.Methods: Thirty-two adult male Sprague– Dawley rats in an experimental study were divided into four equal groups as follow: Control, Indomethacin, BETAINE-indomethacin and ASCORBIC ACID-indomethacin. Control and indomethacin groups received normal saline and BETAINE and ASCORBIC ACID- pretreated rats were administrated BETAINE (1.5% of the total diet) and ASCORBIC ACID (50 mg/kg body weight) for 15 consecutive days, respectively. After 24 h fasting, all of the groups received indomethacin (48 mg/kg body weight) and control group received distilled water.Results: Indomethacin administration increased GASTRIC ULCER occurrence (%) in comparison with control group and BETAINE pretreatment significantly decreased ulcer occurrence (%) when compared to the other groups (P=0.0017). Gastric wall glutathione peroxidase (GPx) activity was significantly lower in indomethacin group in comparison with the other groups (P=0.0012) while, BETAINE and ASCORBIC ACID pretreatment increased GPx activity in comparison with indomethacin group (P=0.0012). Catalase activity was significantly higher in BETAINE-pretreated rats in comparison with indomethacin and ASCORBIC ACID-indomethacin groups (P=0.0015). Lipid peroxidation significantly decreased in BETAINE and ASCORBIC ACID pretreated groups (P=0.0013).Conclusion: These results showed beneficial antioxidant effects of BETAINE against gastric damages induced by indomethacin in rats.

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    APA: Copy

    ALIREZAEI, MASOUD, KHALIGHIAN, NAJMEH, Shokrani, Hamidreza, & TANIDEH, NADER. (2016). ANTIOXIDANT EFFECTS OF BETAINE AGAINST INDOMETHACIN-INDUCED GASTRIC DAMAGE IN RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 24(7), 0-0. SID. https://sid.ir/paper/356936/en

    Vancouver: Copy

    ALIREZAEI MASOUD, KHALIGHIAN NAJMEH, Shokrani Hamidreza, TANIDEH NADER. ANTIOXIDANT EFFECTS OF BETAINE AGAINST INDOMETHACIN-INDUCED GASTRIC DAMAGE IN RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(7):0-0. Available from: https://sid.ir/paper/356936/en

    IEEE: Copy

    MASOUD ALIREZAEI, NAJMEH KHALIGHIAN, Hamidreza Shokrani, and NADER TANIDEH, “ANTIOXIDANT EFFECTS OF BETAINE AGAINST INDOMETHACIN-INDUCED GASTRIC DAMAGE IN RATS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 7, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/356936/en

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